Human suppressor of variegation 4-20 homolog 2 (Drosophila) ELISA Kit | SUV420H2 elisa kit
Human Histone-lysine N-methyltransferase SUV420H2, SUV420H2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM, Dec 2009]
Uniprot Description
SUV420H2: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Belongs to the histone-lysine methyltransferase family. Suvar4-20 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Methyltransferase; Methyltransferase, protein lysine; EC 2.1.1.43; Amino Acid Metabolism - lysine degradation
Chromosomal Location of Human Ortholog: 19q13.42
Cellular Component: nucleoplasm; centric heterochromatin; nuclear heterochromatin; condensed nuclear chromosome, pericentric region
Molecular Function: protein binding; histone lysine N-methyltransferase activity (H4-K20 specific)
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent
Research Articles on SUV420H2
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Product Notes
The Human SUV420H2 suv420h2 (Catalog #AAA9320423) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9320423 ELISA Kit recognizes Human SUV420H2. It is sometimes possible for the material contained within the vial of "suppressor of variegation 4-20 homolog 2 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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