SUSD4 recombinant protein

SUSD4 Protein, Human, Recombinant (mFc Tag)

Cat. Num. AAA8121429

• Gene Names: SUSD4; PRO222; RP11-239E10.4
• Purity: >85% as determined by SDS-PAGE
• Synonyms: SUSD4; SUSD4 Protein; Human; Recombinant (mFc Tag); Human SUSD4/Sushi domain-containing Protein 4 Protein (Fc Tag); PRO222 Protein; sushi domain containing 4; SUSD4 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >85% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Phe290

• Species: Human
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Phe 42
• Tag: C-mouse IgG1-Fc
• Protein Construction: A DNA sequence encoding the human SUSD4 (Q5VX71-3)(Met1-Phe290) was fused with Fc region of mouse IgG at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for SUSD4 recombinant protein

Background: SUSD4, also known as sushi domain-containing protein 4, is a hypothetical cell surface protein whose tissue distribution and function are completely unknown. SUSD4 is detectable in murine brains, eyes, spinal cords, and testis but not other tissues. In brains, SUSD4 is highly expressed in the white matter on oligodendrocytes/axons, and in eyes, it is exclusively expressed on the photoreceptor outer segments. In in vitro complement assays, SUSD4 augments the alternative but not the classical pathway of complement activation at the C3 convertase step. SUSD4 deficiency may cause autism or Fryns syndrome, both of which are genetic diseases with severe abnormal neurological development and/or functions.

References

Kimura K. et al., 2006, Genome Res. 16 (1): 55-65.Davila S. et al., 2010, Genes Immun. 11 (3): 232-8.Tu Z. et al., 2010, Am J Pathol. 176 (5): 2378-84.

NCBI and Uniprot Product Information

• NCBI GI #: 148539593
• NCBI GeneID: 55061
• NCBI Accession #: NP_060452.3
• NCBI GenBank Nucleotide #: NM_017982.3
• UniProt Accession #: Q5VX71; Q6UX62; Q9BSR0; Q9NWG0; D3DTB9
• Molecular Weight: 53,778 Da
• NCBI Official Full Name: sushi domain-containing protein 4 isoform a
• NCBI Official Synonym Full Names: sushi domain containing 4
• NCBI Official Symbol: SUSD4
• NCBI Official Synonym Symbols: PRO222; RP11-239E10.4
• NCBI Protein Information: sushi domain-containing protein 4; YHGM196
• UniProt Protein Name: Sushi domain-containing protein 4
• Protein Family: Sushi domain-containing protein
• UniProt Gene Name: SUSD4
• UniProt Entry Name: SUSD4_HUMAN