Human Snf2-related CREBBP activator protein ELISA Kit | SRCAP elisa kit
Human Helicase SRCAP, SRCAP ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]
Uniprot Description
SRCAP: Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. Defects in SRCAP are the cause of Floating-Harbor syndrome (FLHS). A rare genetic disorder characterized by proportionate short stature, delayed bone age, delayed speech development, and typical facial features. The face is triangular with deep-set eyes, long eyelashes, bulbous nose, wide columella, short philtrum, and thin lips. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Acetyltransferase; Transcription, coactivator/corepressor; Helicase; EC 3.6.1.-; EC 3.6.4.-
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: nucleoplasm; Golgi apparatus; protein complex; perinuclear region of cytoplasm; nucleus
Molecular Function: protein binding; histone acetyltransferase activity; DNA binding; transcription coactivator activity; helicase activity; ATP binding
Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; viral reproduction; histone acetylation
Disease: Floating-harbor Syndrome
Research Articles on SRCAP
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Product Notes
The Human SRCAP srcap (Catalog #AAA9329330) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9329330 ELISA Kit recognizes Human SRCAP. It is sometimes possible for the material contained within the vial of "Snf2-related CREBBP activator protein, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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