Knockout Validation
(Knockout Validation: Lane 1: Wild-type Hela cell lysate; Lane 2: DbH knockout Hela cell lysate; Predicted MW: 69kd Observed MW: 69kd Primary Ab: 5ug/ml Rabbit Anti-Human DbH Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Rabbit anti-Human Dopamine Beta Hydroxylase (DbH) Polyclonal Antibody | anti-DbH antibody
Biotin-Linked Polyclonal Antibody to Dopamine Beta Hydroxylase (DbH)
Knockout Validation
(Knockout Validation: Lane 1: Wild-type Hela cell lysate; Lane 2: DbH knockout Hela cell lysate; Predicted MW: 69kd Observed MW: 69kd Primary Ab: 5ug/ml Rabbit Anti-Human DbH Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Knockout Validation
(Knockout Validation: Lane 1: Wild-type Hela cell lysate; Lane 2: DbH knockout Hela cell lysate; Predicted MW: 69kd Observed MW: 69kd Primary Ab: 5ug/ml Rabbit Anti-Human DbH Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
NCBI and Uniprot Product Information
Uniprot Description
DBH: Conversion of dopamine to noradrenaline. Homotetramer composed of two non-covalently bound disulfide-linked dimers. Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids. Belongs to the copper type II ascorbate-dependent monooxygenase family.
Protein type: Amino Acid Metabolism - tyrosine; Apoptosis; Cell cycle regulation; EC 1.14.17.1; Membrane protein, integral; Motility/polarity/chemotaxis; Oxidoreductase
Chromosomal Location of Human Ortholog: 2 A3|2 19.29 cM
Cellular Component: apical part of cell; axon; cell soma; cytoplasm; cytoplasmic vesicle; dendrite; extracellular space; integral component of membrane; intracellular membrane-bound organelle; membrane; secretory granule membrane; synapse; terminal bouton
Molecular Function: catalytic activity; copper ion binding; dopamine beta-monooxygenase activity; L-ascorbic acid binding; metal ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
Biological Process: associative learning; behavioral response to ethanol; blood vessel remodeling; catecholamine biosynthetic process; cytokine production; dopamine catabolic process; fear response; glucose homeostasis; homoiothermy; leukocyte mediated immunity; leukocyte migration; locomotory behavior; maternal behavior; memory; norepinephrine biosynthetic process; octopamine biosynthetic process; octopamine metabolic process; positive regulation of vasoconstriction; regulation of cell proliferation; response to amphetamine; response to pain; visual learning
Research Articles on DbH
Similar Products
Product Notes
The DbH dbh (Catalog #AAA2093287) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Biotin-Linked Polyclonal Antibody to Dopamine Beta Hydroxylase (DbH) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Dopamine Beta Hydroxylase (DbH) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the DbH dbh for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Dopamine Beta Hydroxylase (DbH), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
