Western Blot (WB)
(Western blot analysis of extracts from rat brain cells, using CDK5R1 antibody.)
Rabbit CDK5R1 Polyclonal Antibody | anti-CDK5R1 antibody
CDK5R1 Antibody
Immunofluorescence: 1:100~1:500
Western Blot (WB)
(Western blot analysis of extracts from rat brain cells, using CDK5R1 antibody.)
Western Blot (WB)
(Western blot analysis of extracts from rat brain cells, using CDK5R1 antibody.)
Immunofluorescence (IF)
(Immunofluorescence analysis of HeLa cells, using CDK5R1 antibody.)
Immunofluorescence (IF)
(Immunofluorescence analysis of HeLa cells, using CDK5R1 antibody.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]
Uniprot Description
CDK5R1: activator of cyclin-dependent kinase 5 (CDK5). Required for proper development of the central nervous system. The p35 form of this protein is cleaved by calpain, generating a p25 form, resulting in the prolonged activation and relocalization of the CDK5 from the cell periphery to nuclear and perinuclear regions. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease, leading to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
Protein type: Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: intracellular membrane-bound organelle; cyclin-dependent protein kinase 5 activator complex; contractile fiber; postsynaptic density; dendrite; dendritic spine; cytosol; nucleoplasm; growth cone; cell soma; membrane; perinuclear region of cytoplasm; axon; cytoplasm; plasma membrane; neuromuscular junction; nucleus
Molecular Function: protein serine/threonine kinase activator activity; protein binding; ephrin receptor binding; cyclin-dependent protein kinase activity; cadherin binding; cyclin-dependent protein kinase 5 activator activity; calcium ion binding; kinase activity; protein kinase binding; protein kinase activity
Biological Process: axon guidance; superior olivary nucleus maturation; regulation of neuron differentiation; neuron migration; rhythmic process; negative regulation of axon extension; neuron differentiation; positive regulation of neuron apoptosis; ephrin receptor signaling pathway; cerebellum development; neuron adhesion; neurite development; layer formation in the cerebral cortex; serine phosphorylation of STAT3 protein; acetylcholine receptor signaling, muscarinic pathway; hippocampus development; axonal fasciculation; peptidyl-threonine phosphorylation; cell proliferation; peptidyl-serine phosphorylation; embryonic development; ionotropic glutamate receptor signaling pathway; regulation of actin cytoskeleton organization and biogenesis; brain development; regulation of cyclin-dependent protein kinase activity; negative regulation of transcription, DNA-dependent
Research Articles on CDK5R1
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Product Notes
The CDK5R1 cdk5r1 (Catalog #AAA9404625) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CDK5R1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CDK5R1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). Western blotting: 1:500~1:3000 Immunofluorescence: 1:100~1:500. Researchers should empirically determine the suitability of the CDK5R1 cdk5r1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CDK5R1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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