SPARCL1 / SPARC-like 1 recombinant protein
Recombinant Mouse SPARCL1 / SPARC-like 1 Protein (His tag)
Gene Names
Sparcl1; Sc1; Ecm2; hevin; mast9
Purity
> 85 % as determined by SDS-PAGE
Synonyms
SPARCL1 / SPARC-like 1; Recombinant Mouse SPARCL1 / SPARC-like 1 Protein (His tag); SPARCL1; Ecm2; Sc1; SPARCL1 / SPARC-like 1 recombinant protein
Host
Human Cells
Purity/Purification
> 85 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
650
Application Notes
The recombinant mouse SPARCL1 comprises 645 amino acids and has a predicted molecular mass of 72.2 kDa. The apparent molecular mass of the protein is approximately 118 kDa in SDS-PAGE under reducing conditions.
Predicted N Terminal
Ile 17
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
Related Product Information for SPARCL1 / SPARC-like 1 recombinant protein
Background: SPARC-like protein 1 (SPARCL1; also known as SC1, high endothelial venule protein, or hevin) is an extracellular matrix-associated, secreted glycoprotein belonging to the secreted protein acidic and rich in cysteine (SPARC) family of matricellular proteins. It contains three conserved structural domains that are implicated in the regulation of cell adhesion, migration, and proliferation. SPARCL1 is expressed during embryogenesis and tissue remodeling and is especially prominent in brain and vasculature. Its down-regulation in a number of cancers and the possibility of its functional compensation by SPARC has led to recent interest in hevin as a tumor suppressor and regulator of angiogenesis. SPARCL1 has antiadhesive properties, and loss of SPARCL1 expression is associated with increased proliferative activity and cell cycle progression. It is suggested that it may influence multiple cellular processes during distinct stages of brain development and function. In addition, SPARCL1 can influence the function of astroglial cells in the developing and mature central nervous system (CNS).
Description: A DNA sequence encoding the mouse SPARCL1 (EDL20231.1) (Met1-Phe650) was expressed with a C-terminal polyhistidine tag.
Description: A DNA sequence encoding the mouse SPARCL1 (EDL20231.1) (Met1-Phe650) was expressed with a C-terminal polyhistidine tag.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
72,287 Da
NCBI Official Full Name
SPARC-like 1 (mast9, hevin), isoform CRA_a
NCBI Official Synonym Full Names
SPARC-like 1
NCBI Official Symbol
Sparcl1
NCBI Official Synonym Symbols
Sc1; Ecm2; hevin; mast9
NCBI Protein Information
SPARC-like protein 1
UniProt Protein Name
SPARC-like protein 1
UniProt Gene Name
Sparcl1
UniProt Synonym Gene Names
Ecm2; Sc1
Uniprot Description
SPARCL1: Belongs to the SPARC family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 5 E5|5 50.55 cM
Cellular Component: extracellular space; synapse
Molecular Function: calcium ion binding; collagen binding; extracellular matrix binding
Biological Process: anatomical structure development
Research Articles on SPARCL1 / SPARC-like 1
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Product Notes
The SPARCL1 / SPARC-like 1 sparcl1 (Catalog #AAA2546922) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant mouse SPARCL1 comprises 645 amino acids and has a predicted molecular mass of 72.2 kDa. The apparent molecular mass of the protein is approximately 118 kDa in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the SPARCL1 / SPARC-like 1 sparcl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SPARCL1 / SPARC-like 1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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