Testing Data
(Profile of anti-SPARCL1 reactivity on HL60 cells analyzed by flow cytometry.)
Rabbit anti-Human SPARCL1 Monoclonal Antibody | anti-SPARCL1 antibody
Recombinant Anti-SPARCL1 Antibody (PE), Rabbit Monoclonal
Gene Names
SPARCL1; SC1; MAST9; PIG33; MAST 9
Reactivity
Human
Applications
Flow Cytometry, Functional Assay
Purity
Protein A
Synonyms
SPARCL1; Monoclonal Antibody; Recombinant Anti-SPARCL1 Antibody (PE); Rabbit Monoclonal; SPARCL1 Antibody (PE); Rabbit MAb; SPARC like 1; Anti-MAST 9 Antibody; Anti-MAST9 Antibody; Anti-PIG33 Antibody; Anti-SC1 Antibody; Anti-SPARCL1 Antibody; anti-SPARCL1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
Rabbit IgG
Clone Number
390
Specificity
Human SPARCL1
Purity/Purification
Protein A
Form/Format
Liquid; Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Concentration
5ul/Test, 0.1mg/ml (varies by lot)
Applicable Applications for anti-SPARCL1 antibody
Flow Cytometry (FC/FACS/FCM)
Antibody Type
Recombinant Antibody
Immunogen
Recombinant Human SPARCL1 protein
Conjugation
PE
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human SPARCL1 (rh SPARCL1) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Preparation and Storage
This antibody can be stored at 2-8 degree C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Testing Data
(Profile of anti-SPARCL1 reactivity on HL60 cells analyzed by flow cytometry.)
Testing Data
(Profile of anti-SPARCL1 reactivity on HL60 cells analyzed by flow cytometry.)
Related Product Information for anti-SPARCL1 antibody
SPARC-like protein 1 (SPARCL1; also known as SC1, high endothelial venule protein, or hevin) is an extracellular matrix-associated, secreted glycoprotein belonging to the secreted protein acidic and rich in cysteine (SPARC) family of matricellular proteins. It contains three conserved structural domains that are implicated in the regulation of cell adhesion, migration, and proliferation. SPARCL1 is expressed during embryogenesis and tissue remodeling and is especially prominent in brain and vasculature. Its down-regulation in a number of cancers and the possibility of its functional compensation by SPARC has led to recent interest in hevin as a tumor suppressor and regulator of angiogenesis. SPARCL1 has antiadhesive properties, and loss of SPARCL1 expression is associated with increased proliferative activity and cell cycle progression. It is suggested that it may influence multiple cellular processes during distinct stages of brain development and function. Besides, SPARCL1 can influence the function of astroglial cells in the developing and mature central nervous system (CNS).
References
Sullivan MM, et al. (2004) Hevin/SC1, a matricellular glycoprotein and potential tumor-suppressor of the SPARC/BM-40/Osteonectin family. Int J Biochem Cell Biol. 36(6): 991-6.Esposito I, et al. (2007) Tumor-suppressor function of SPARC-like protein 1/Hevin in pancreatic cancer. Neoplasia. 9(1): 8-17.Weimer JM, et al. (2008) A BAC transgenic mouse model to analyze the function of astroglial SPARCL1 (SC1) in the central nervous system. Glia. 56(9): 935-41.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
75,208 Da
NCBI Official Full Name
SPARC-like protein 1 isoform 1
NCBI Official Synonym Full Names
SPARC-like 1 (hevin)
NCBI Official Symbol
SPARCL1
NCBI Official Synonym Symbols
SC1; MAST9; PIG33; MAST 9
NCBI Protein Information
SPARC-like protein 1; high endothelial venule protein; proliferation-inducing protein 33
Protein Family
Research Articles on SPARCL1
Similar Products
Product Notes
The SPARCL1 (Catalog #AAA8100408) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Anti-SPARCL1 Antibody (PE), Rabbit Monoclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SPARCL1 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS/FCM). Researchers should empirically determine the suitability of the SPARCL1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SPARCL1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
