Mouse SMAD family member 6 ELISA Kit | SMAD6 elisa kit
Mouse Mothers against decapentaplegic homolog 6, SMAD6 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SMAD6: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions. Interacts with NEDD4L. Interacts with WWP1. Interacts with RNF111 and AXIN1. Interacts with TGF-beta type I receptor superfamily members, SMAD1, HOXC8 and HOXC9. Interacts with STAMBP and PRKX. Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue. Belongs to the dwarfin/SMAD family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription factor
Cellular Component: transcription factor complex; protein complex; intracellular; nucleus
Molecular Function: identical protein binding; protein binding; DNA binding; metal ion binding; ubiquitin protein ligase binding; chromatin binding; transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity; transcription factor activity
Biological Process: fat cell differentiation; transcription, DNA-dependent; cell-substrate adhesion; negative regulation of BMP signaling pathway; BMP signaling pathway; negative regulation of cell proliferation; zygotic determination of dorsal/ventral axis; negative regulation of vasodilation; regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; positive regulation of vasoconstriction; immune response; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of apoptosis
Research Articles on SMAD6
Similar Products
Product Notes
The Mouse SMAD6 smad6 (Catalog #AAA9340519) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9340519 ELISA Kit recognizes Mouse SMAD6. It is sometimes possible for the material contained within the vial of "SMAD family member 6, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
