Western Blot (WB)
(Western blot analysis of extracts from Jurkat cells, treated with etoposide (25uM, 1hour), using Dipeptidyl-peptidase 1 (heavy chain, Cleaved-Arg394) antibody.)
anti-Human Dipeptidyl-peptidase 1 Antibody | anti-DPP1 antibody
Dipeptidyl-peptidase 1 (heavy chain, Cleaved-Arg394) Antibody
ELISA: 1:20000
Western Blot (WB)
(Western blot analysis of extracts from Jurkat cells, treated with etoposide (25uM, 1hour), using Dipeptidyl-peptidase 1 (heavy chain, Cleaved-Arg394) antibody.)
Western Blot (WB)
(Western blot analysis of extracts from Jurkat cells, treated with etoposide (25uM, 1hour), using Dipeptidyl-peptidase 1 (heavy chain, Cleaved-Arg394) antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. [provided by RefSeq, Nov 2015]
Uniprot Description
Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII.
Research Articles on DPP1
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Product Notes
The DPP1 ctsc (Catalog #AAA853811) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Dipeptidyl-peptidase 1 (heavy chain, Cleaved-Arg394) Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Dipeptidyl-peptidase 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:500~1:1000 ELISA: 1:20000. Researchers should empirically determine the suitability of the DPP1 ctsc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Dipeptidyl-peptidase 1, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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