ZIP13 Blocking Peptide | Slc39a13 blocking peptide

ZIP13 Peptide

Cat. Num. AAA151872

• Applications: Blocking (BL)
• Synonyms: ZIP13; ZIP13 Peptide; Zinc transporter ZIP13; LIV-1 subfamily of ZIP zinc transporter 9; LZT-Hs9; solute carrier family 39 (zinc transporter); member 13; Slc39a13 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 371

• Applicable Applications for Slc39a13 blocking peptide: Blocking (BL)
• Application Notes: ZIP13 peptide is used for blocking the activity of ZIP13 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 14 amino acid peptide near the amino terminus of human ZIP13.
• Preparation and Storage: Store ZIP13 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 190014617
• NCBI GeneID: 91252
• NCBI Accession #: NP_001121697
• NCBI GenBank Nucleotide #: NM_001128225.2
• UniProt Accession #: Q96H72; Q659D9; Q8N7C9; Q8WV10; D3DQR6; D3DQR7; E9PLY1; E9PQV3
• Molecular Weight: 38,425 Da
• NCBI Official Full Name: zinc transporter ZIP13 isoform a
• NCBI Official Synonym Full Names: solute carrier family 39 (zinc transporter), member 13
• NCBI Official Symbol: SLC39A13
• NCBI Protein Information: zinc transporter ZIP13; LZT-Hs9; zrt- and Irt-like protein 13; LIV-1 subfamily of ZIP zinc transporter 9; solute carrier family 39 (metal ion transporter), member 13
• UniProt Protein Name: Zinc transporter ZIP13
• Protein Family: Zinc transporter
• UniProt Gene Name: SLC39A13
• UniProt Synonym Gene Names: ZIP13; LZT-Hs9; ZIP-13
• UniProt Entry Name: S39AD_HUMAN

NCBI Description

This gene encodes a member of the LIV-1 subfamily of the ZIP transporter family. The encoded transmembrane protein functions as a zinc transporter. Mutations in this gene have been associated with the spondylocheiro dysplastic form of Ehlers-Danlos syndrome.[provided by RefSeq, Mar 2010]

Uniprot Description

SLC39A13: Acts as a zinc-influx transporter. Defects in SLC39A13 are the cause of Ehlers-Danlos syndrome-like spondylocheirodysplasia (SCD-EDS). SCD- EDS is a 'spondylocheiro dysplastic form of Ehlers-Danlos syndrome'. The syndrome consists of a generalized skeletal dysplasia involving mainly the spine (spondylo) and striking clinical abnormalities of the hands (cheiro) in addition to the EDS-like features. Clinical features included postnatal growth retardation, moderate short stature, protuberant eyes with bluish sclerae, hands with finely wrinkled palms, atrophy of the thenar muscles, and tapering fingers. Patients have thin, hyperelastic skin and hypermobile small joints consistent with an Ehlers- Danlos-like phenotype. Radiologic features included mild to moderate platyspondyly, mild to moderate osteopenia of the spine, small ileum, flat proximal femoral epiphyses, short, wide femoral necks, and broad metaphyses (elbows, knees, wrists, and interphalangeal joints). Belongs to the ZIP transporter (TC 2.A.5) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; integral to membrane; integral to Golgi membrane

Molecular Function: protein homodimerization activity; zinc ion transmembrane transporter activity

Biological Process: cellular zinc ion homeostasis

Disease: Spondylocheirodysplasia, Ehlers-danlos Syndrome-like