Human solute carrier family 26, member 8 ELISA Kit | SLC26A8 elisa kit
Human Testis anion transporter 1, SLC26A8 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. The expression of this gene appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2010]
Uniprot Description
SLC26A8: Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 6p21
Cellular Component: integral to membrane; plasma membrane
Molecular Function: chloride channel activity; protein binding; anion:anion antiporter activity; sulfate transmembrane transporter activity; oxalate transmembrane transporter activity; secondary active sulfate transmembrane transporter activity
Biological Process: sperm motility; meiotic cell cycle; multicellular organismal development; sulfate transport; chloride transport; oxalate transport; sperm capacitation; anion transport
Disease: Spermatogenic Failure 3
Research Articles on SLC26A8
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Product Notes
The Human SLC26A8 slc26a8 (Catalog #AAA9335685) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9335685 ELISA Kit recognizes Human SLC26A8. It is sometimes possible for the material contained within the vial of "solute carrier family 26, member 8, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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