Rabbit anti-Human SLC26A8 Polyclonal Antibody | anti-SLC26A8 antibody

SLC26A8 Antibody

Cat. Num. AAA7006185

• Gene Names: SLC26A8; TAT1; SPGF3
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry, Immunofluorescence
• Purity: >95%,Protein G purified
• Synonyms: SLC26A8; Polyclonal Antibody; SLC26A8 Antibody; Testis anion transporter 1; Anion exchange transporter; Solute carrier family 26 member 8; anti-SLC26A8 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%,Protein G purified
• Form/Format: Liquid
• Sequence Length: 970

• Applicable Applications for anti-SLC26A8 antibody: ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Immunogen: Recombinant human Testis anion transporter 1 protein
• Conjugation: Non-conjugated
• Storage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Preparation and Storage: Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human testis tissue using MBS7006185 at dilution of 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human pancreatic cancer using MBS7006185 at dilution of 1:100)

Immunohistochemistry (IHC)

(Immunofluorescent analysis of HepG2 cells using MBS7006185 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))

Related Product Information for anti-SLC26A8 antibody

Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a moleculer complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation.

NCBI and Uniprot Product Information

• NCBI GI #: 301601599
• NCBI GeneID: 116369
• NCBI Accession #: NP_001180405.1
• NCBI GenBank Nucleotide #: NM_001193476.1
• UniProt Accession #: Q96RN1; Q5JVR5; Q812C7; Q8TC65; Q96MA0; Q96PK8
• Molecular Weight: 85,680 Da
• NCBI Official Full Name: testis anion transporter 1 isoform a
• NCBI Official Synonym Full Names: solute carrier family 26 member 8
• NCBI Official Symbol: SLC26A8
• NCBI Official Synonym Symbols: TAT1; SPGF3
• NCBI Protein Information: testis anion transporter 1
• UniProt Protein Name: Testis anion transporter 1
• Protein Family: Testis anion transporter
• UniProt Gene Name: SLC26A8
• UniProt Entry Name: S26A8_HUMAN

NCBI Description

This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. The expression of this gene appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2010]

Uniprot Description

SLC26A8: Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter; Transporter, SLC family; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: anion:anion antiporter activity; bicarbonate transmembrane transporter activity; chloride channel activity; oxalate transmembrane transporter activity; protein binding; secondary active sulfate transmembrane transporter activity; sulfate transmembrane transporter activity

Biological Process: anion transport; bicarbonate transport; chloride transport; meiotic cell cycle; multicellular organismal development; oxalate transport; regulation of intracellular pH; regulation of membrane potential; sperm capacitation; sperm motility; sulfate transport

Disease: Spermatogenic Failure 3