Rabbit anti-Human SERPINB8 Polyclonal Antibody | anti-SERPINB8 antibody

SERPINB8, CT (SERPINB8, PI8, Serpin B8, Cytoplasmic antiproteinase 2, Peptidase inhibitor 8) (APC)

Cat. Num. AAA6346329

• Gene Names: SERPINB8; PI8; CAP2
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SERPINB8; Polyclonal Antibody; CT (SERPINB8; PI8; Serpin B8; Cytoplasmic antiproteinase 2; Peptidase inhibitor 8) (APC); Peptidase inhibitor 8; anti-SERPINB8 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-SERPINB8 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: SERPINB8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 274-301 amino acids from the C-terminal region of human SERPINB8.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(SERPINB8 Antibody (C-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the SERPINB8 antibody detected the SERPINB8 protein (arrow).)

Related Product Information for anti-SERPINB8 antibody

The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N-and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).

Product Categories/Family for anti-SERPINB8 antibody

Antibodies; Protease Inhibitors

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): de Koning, P.J., et al. Pancreas 38(4):461-467(2009). Luke, M.M., et al. Stroke 40(2):363-368(2009). Shiffman, D., et al. Arterioscler. Thromb. Vasc. Biol. 28(1):173-179(2008). Denoeud, F., et al. Genome Res. 17(6):746-759(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 38504673
• NCBI GeneID: 5271
• NCBI Accession #: NP_002631.3
• NCBI GenBank Nucleotide #: NM_002640.3
• UniProt Accession #: P50452; Q7Z2V6; Q8N178; B4DTW2
• Molecular Weight: 22,134 Da
• NCBI Official Full Name: serpin B8 isoform a
• NCBI Official Synonym Full Names: serpin family B member 8
• NCBI Official Symbol: SERPINB8
• NCBI Official Synonym Symbols: PI8; CAP2
• NCBI Protein Information: serpin B8
• UniProt Protein Name: Serpin B8
• Protein Family: Serpin
• UniProt Gene Name: SERPINB8
• UniProt Synonym Gene Names: PI8; CAP-2; CAP2; PI-8
• UniProt Entry Name: SPB8_HUMAN

NCBI Description

The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).[supplied by OMIM, Jan 2010]