SDS-PAGE
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SLA recombinant protein
SLA protein (GST tag) (His tag)
Gene Names
SLA; SLA1; SLAP
Purity
> 90% by SDS-PAGEPurified by using proprietary chromatopraphic techniques
Synonyms
SLA; SLA protein (GST tag) (His tag); Soluble Liver Antigen; SLA recombinant protein
Host
E.coli
Purity/Purification
> 90% by SDS-PAGE
Purified by using proprietary chromatopraphic techniques
Purified by using proprietary chromatopraphic techniques
Form/Format
Liquid in 50mM Tris pH 8.0, 150mM NaCl, 10uM PLP, 10% glycerol, 1mM EDTA, 2mM DTT.
Concentration
1.0mg/ml (varies by lot)
Sequence Length
276
Protein Type
Recombinant
Biological Significance
Soluble liver antigen antibodies are detected in 10-30% of patients with type 1 autoimmune hepatitis (AIH)
Species
Human
Tag/Conjugate
His-GST tag
Biohazard
Recombinant protein with His tag. Use Standard laboratory precautions when handling this material.
Residues
1-501aa
Expression
Increased SLA expression has been reported in some instances of bone marrow cancer. SLA is expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas.
Implications in Disease
Defects in SLA expression have been reported in several bone marrow cancers but its role is not fully understood. Other diseases associated with SLA include prontocerebellar hypoplasia type 2d, causing mental retardation in the foetus.
Post-Translational Modifications
Ubiquitination of SLA occurs at Lys60, LYS93, LYS104, LYS117, LYS252, and LYS264.
Preparation and Storage
Ships on blue ice. Upon receipt store at -70°C.
SDS-PAGE
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SDS-PAGE
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Related Product Information for SLA recombinant protein
Purified recombinant SLA protein (GST tag) (His tag)
Product Categories/Family for SLA recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
88 kDa
NCBI Official Full Name
src-like-adapter isoform a
NCBI Official Synonym Full Names
Src-like-adaptor
NCBI Official Symbol
SLA
NCBI Official Synonym Symbols
SLA1; SLAP
NCBI Protein Information
src-like-adapter
UniProt Protein Name
Src-like-adapter
Protein Family
UniProt Gene Name
SLA
UniProt Synonym Gene Names
SLAP; SLAP1; SLAP-1; hSLAP
UniProt Entry Name
SLAP1_HUMAN
Uniprot Description
SLAP: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 8q24
Cellular Component: endosome
Molecular Function: protein binding; SH3/SH2 adaptor activity
Biological Process: positive regulation of signal transduction
Research Articles on SLA
Similar Products
Product Notes
The SLA sla (Catalog #AAA5304501) is a Recombinant Protein produced from E.coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SLA, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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