Structure
D-AP5, inhibitor
D-AP5
Purity
98.00%
Synonyms
D-AP5; D-APV; D-2-Amino-5-phosphonovaleric acid; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
H2O: 50mg/mL (253.64mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C5H12NO5P
SMILES
N[C@H](CCCP(O)(O)=O)C(O)=O
CAS Number
79055-68-8
Target & IC50
Others
In Vitro
D-AP5 is annMDA receptor antagonist. Chronic intraventricular injection of D-AP5 can cause dose-dependent parallel damage to spatial learning and long-term enhancement (LTP) in vivo. When preventing spatial learning, the concentration of D-AP5 in the brain cannot cause any measurable sensorimotor disturbances. Compared with the test, D-AP5 infusion will cause a gradual decrease in swimming speed. D-AP5 causes sensorimotor disturbances in space tasks, but gradually deteriorates due to the inability of animals to learn. Rats treated with D-AP5 showed spatially dependent delay-dependent defects in the delayed matching placement protocol of the water maze.
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for D-AP5, inhibitor
D-AP5 is anMDA receptor antagonist.
References
Davis S, et al. ThenMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J Neurosci. 1992 Jan;12(1):21-34.
Davis S, et al. ThenMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J Neurosci. 1992 Jan;12(1):21-34.
Morris RG, et al. N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of thenMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning. Eur J Neurosci. 2013 Mar;37(5):700-17.
Morris RG, et al. N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of thenMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning. Eur J Neurosci. 2013 Mar;37(5):700-17.
Davis S, et al. ThenMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J Neurosci. 1992 Jan;12(1):21-34.
Morris RG, et al. N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of thenMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning. Eur J Neurosci. 2013 Mar;37(5):700-17.
Morris RG, et al. N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of thenMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning. Eur J Neurosci. 2013 Mar;37(5):700-17.
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Product Notes
The D-AP5 (Catalog #AAA5752970) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "D-AP5, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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