Mouse NAD-dependent deacetylase sirtuin-3 ELISA Kit | Sirt3 elisa kit
Mouse NAD-dependent deacetylase sirtuin-3 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SIRT3: a soluble mitochondrial NAD-dependent protein deacetylase. Can deacetylate and thereby activate a central metabolic regulator in the mitochondrial matrix, glutamate dehydrogenase. Mitochondrial proteins are hyperacetylated in SIRT3-deficient mice, but not in SIRT4 or SIRT5 deficient mice. SIRT3-deficient mice have no obvious metabolic phenotype, and the process of adaptive thermogenesis is normal. Can deacetylate and activate isocitrate dehydrogenase 2, an enzyme that participates in regulation of the citric acid cycle and the regeneration of antioxidants. Inhibited by nicotinamide, but not by trichostatin A. Its unprocessed form is enzymatically inactive. It is processed by mitochondrial processing peptidase (MPP) in the mitochondrial matrix to give an enzymatically active 28 kDa product.
Protein type: Deacetylase; EC 3.5.1.-; Mitochondrial
Chromosomal Location of Human Ortholog: 7|7 F4-F5
Cellular Component: cytoplasm; membrane; mitochondrial inner membrane; mitochondrial matrix; mitochondrion
Molecular Function: enzyme binding; NAD-dependent histone deacetylase activity (H3-K14 specific); protein binding; zinc ion binding
Biological Process: aerobic respiration; positive regulation of insulin secretion; protein amino acid deacetylation
Research Articles on Sirt3
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Product Notes
The Mouse Sirt3 sirt3 (Catalog #AAA9428142) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9428142 ELISA Kit recognizes Mouse Sirt3. It is sometimes possible for the material contained within the vial of "NAD-dependent deacetylase sirtuin-3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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