Rabbit anti-Mouse SIRT3 Polyclonal Antibody | anti-SIRT3 antibody

SIRT3 Polyclonal Antibody

Cat. Num. AAA2556240

• Gene Names: Sirt3; Sir2l3; AI848213; 2310003L23Rik
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Affinity Purification
• Synonyms: SIRT3; Polyclonal Antibody; SIRT3 Polyclonal Antibody; hSIRT 3; hSIRT3; Mitochondrial nicotinamide adenine dinucleotide dependent deacetylase; NAD dependent deacetylase sirtuin 3 mitochondrial; NAD-dependent protein deacetylase sirtuin-3; mitochondrial; Regulatory protein SIR2 homolog 3; Silent mating type information regulation 2 S.cerevisiae homolog 3; Sir 2 like 3; SIR 2 like protein 3; SIR 3; SIR2 L3; Sir2 like 3; SIR2 like protein 3; SIR2-like protein 3; SIR2L3; SIR3; SIRT 3; Sirtuin 3; Sirtuin silent mating type information regulation 2 homolog 3 (S. cerevisiae); Sirtuin type 3; Sirtuin3; anti-SIRT3 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 100 mug/ml BSA and 50% glycerol.
• Concentration: 500 mug/mL (varies by lot)
• Sequence Length: 257

• Applicable Applications for anti-SIRT3 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: KLH conjugated synthetic peptide corresponding to Mouse SIRT3
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western Blot analysis of various samples using SIRT3 Polyclonal Antibody at dilution of 1:600.)

Related Product Information for anti-SIRT3 antibody

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.

Product Categories/Family for anti-SIRT3 antibody

Cancer; Cell Biology; Cardiovascular; Epigenetics and Nuclear Signaling; Metabolism

NCBI and Uniprot Product Information

• NCBI GI #: 188219522
• NCBI GeneID: 64384
• NCBI Accession #: NP_001120823.1
• NCBI GenBank Nucleotide #: NM_001127351.1
• UniProt Accession #: Q8R104; Q9EPA8; B9W0A9; C6ZII7
• Molecular Weight: Calculated: 28kDa; Observed: 28kDa
• NCBI Official Full Name: NAD-dependent protein deacetylase sirtuin-3 isoform 1
• NCBI Official Synonym Full Names: sirtuin 3
• NCBI Official Symbol: Sirt3
• NCBI Official Synonym Symbols: Sir2l3; AI848213; 2310003L23Rik
• NCBI Protein Information: NAD-dependent protein deacetylase sirtuin-3
• UniProt Protein Name: NAD-dependent protein deacetylase sirtuin-3
• Protein Family: NAD-dependent protein deacetylase sirtuin
• UniProt Gene Name: Sirt3
• UniProt Synonym Gene Names: Sir2l3; mSIR2L3

Uniprot Description

NAD-dependent protein deacetylase (PubMed:23835326, PubMed:17923681, PubMed:18794531, PubMed:21172655). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:23835326, PubMed:17923681, PubMed:18794531, PubMed:21172655). Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP synthase subunit ATP5PO (PubMed:16790548, PubMed:18794531, PubMed:21172655). Contributes to the regulation of the cellular energy metabolism (PubMed:23835326). Important for regulating tissue-specific ATP levels (PubMed:18794531, PubMed:24252090). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301).