SH3 and PX domain-containing protein 2B (SH3PXD2B) Recombinant Protein | SH3PXD2B recombinant protein

Recombinant Human SH3 and PX domain-containing protein 2B (SH3PXD2B) , partial

• Gene Names: SH3PXD2B; FTHS; HOFI; TKS4; TSK4; FAD49; KIAA1295
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: SH3 and PX domain-containing protein 2B (SH3PXD2B); Recombinant Human SH3 and PX domain-containing protein 2B (SH3PXD2B); partial; SH3PXD2B recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 911

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 63055059
• NCBI GeneID: 285590
• NCBI Accession #: NP_001017995.1
• NCBI GenBank Nucleotide #: NM_001017995.2
• UniProt Accession #: A1X283; Q9P2Q1; B6F0V2
• Molecular Weight: 101,579 Da
• NCBI Official Full Name: SH3 and PX domain-containing protein 2B isoform a
• NCBI Official Synonym Full Names: SH3 and PX domains 2B
• NCBI Official Symbol: SH3PXD2B
• NCBI Official Synonym Symbols: FTHS; HOFI; TKS4; TSK4; FAD49; KIAA1295
• NCBI Protein Information: SH3 and PX domain-containing protein 2B
• UniProt Protein Name: SH3 and PX domain-containing protein 2B
• Protein Family: SH3 and PX domain-containing protein
• UniProt Gene Name: SH3PXD2B
• UniProt Synonym Gene Names: FAD49; KIAA1295; TKS4

NCBI Description

This gene encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. The encoded protein is required for podosome formation and is involved in cell adhesion and migration of numerous cell types. Mutations in this gene are the cause of Frank-ter Haar syndrome (FTHS), and also Borrone Dermato-Cardio-Skeletal (BDCS) syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Uniprot Description

Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation ().