Western Blot (WB)
(All lanes : Anti-SH3PXD2B Antibody (C-Term) at 1:2000 dilutionLane 1: U-251 MG whole cell lysateLane 2: U-87 MG whole cell lysateLane 3: SH-SY5Y whole cell lysateLysates/proteins at 20 ug per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 102 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Rabbit anti-Human SH3PXD2B Polyclonal Antibody | anti-SH3PXD2B antibody
SH3PXD2B Antibody (C-Term)
Western Blot (WB)
(All lanes : Anti-SH3PXD2B Antibody (C-Term) at 1:2000 dilutionLane 1: U-251 MG whole cell lysateLane 2: U-87 MG whole cell lysateLane 3: SH-SY5Y whole cell lysateLysates/proteins at 20 ug per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 102 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Western Blot (WB)
(All lanes : Anti-SH3PXD2B Antibody (C-Term) at 1:2000 dilutionLane 1: U-251 MG whole cell lysateLane 2: U-87 MG whole cell lysateLane 3: SH-SY5Y whole cell lysateLysates/proteins at 20 ug per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 102 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. The encoded protein is required for podosome formation and is involved in cell adhesion and migration of numerous cell types. Mutations in this gene are the cause of Frank-ter Haar syndrome (FTHS), and also Borrone Dermato-Cardio-Skeletal (BDCS) syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Uniprot Description
SH3PXD2B: Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation. Defects in SH3PXD2B are the cause of Frank-Ter Haar syndrome (FTHS). It is a syndrome characterized by brachycephaly, wide fontanels, prominent forehead, hypertelorism, prominent eyes, macrocornea with or without glaucoma, full cheeks, small chin, bowing of the long bones and flexion deformity of the fingers. Belongs to the SH3PXD2 family.
Protein type: Lipid-binding
Chromosomal Location of Human Ortholog: 5q35.1
Cellular Component: cell junction; cell projection; cytoplasm; podosome
Molecular Function: phosphatidylinositol 3-phosphate binding; phosphatidylinositol-5-phosphate binding; protein binding; SH2 domain binding
Biological Process: cell differentiation; extracellular matrix disassembly; eye development; heart development; positive regulation of fat cell differentiation; skeletal development; superoxide metabolic process
Disease: Frank-ter Haar Syndrome
Research Articles on SH3PXD2B
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Product Notes
The SH3PXD2B sh3pxd2b (Catalog #AAA9217225) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SH3PXD2B Antibody (C-Term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SH3PXD2B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB:~~1:2000. Researchers should empirically determine the suitability of the SH3PXD2B sh3pxd2b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SH3PXD2B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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