Alpha-1-Antitrypsin (a1AT) Recombinant Protein | a1AT recombinant protein
Recombinant Alpha-1-Antitrypsin (a1AT)
MGHHHHHHSGSEF-AQETDTSQQD QSPTYRKISS NLADFAFSLY RELVHQSNTS NIFFSPMSIT TAFAMLSLGS KGDTRKQILE GLEFNLTQIP EADIHKAFHH LLQTLNRPDS ELQLNTGNGL FVNKNLKLVE KFLEEVKNNY HSEAFSVNFA DSEEAKKVIN DYVEK
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
NCBI and Uniprot Product Information
Uniprot Description
SERPINA1: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD). A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide; Inhibitor
Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum
Molecular Function: serine-type endopeptidase inhibitor activity; identical protein binding; protein binding; protease binding; endopeptidase inhibitor activity; glycoprotein binding
Biological Process: response to chromate; response to inorganic substance; response to triglyceride; response to cytokine stimulus; response to lead ion; acute-phase response; response to hypoxia; response to methanol; response to lipopolysaccharide; inflammatory response; response to organic cyclic substance; response to estradiol stimulus
Research Articles on a1AT
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Product Notes
The a1AT serpina1 (Catalog #AAA2009415) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Alpha-1-Antitrypsin (a1AT) can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the a1AT serpina1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: The target protein is fused with N-terminal His-Tag, its sequence is listed below. MGHHHHHHSG SEF-AQETDT SQQD QSPTYRKISS NLADFAFSLY RELVHQSNTS NIFFSPMSIT TAFAMLSLGS KGDTRKQILE GLEFNLTQIP EADIHKAFHH LLQTLNRPDS ELQLNTGNGL FVNKNLKLVE KFLEEVKNNY HSEAFSVNFA DSEEAKKVIN DYVEK. It is sometimes possible for the material contained within the vial of "Alpha-1-Antitrypsin (a1AT), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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