CD31/PECAM-1 recombinant protein

Recombinant Human CD31/PECAM-1 Protein (C-Fc)

Cat. Num. AAA2557176

• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: CD31/PECAM-1; Recombinant Human CD31/PECAM-1 Protein (C-Fc); Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA; PECA1; CD31; PECAM1; CD31/PECAM-1 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH7.4.
• Sequence: Gln28-Lys601
• Sequence Length: 702

• Species: Human
• Endotoxin: < 1.0 EU per mug as determined by the LAL method.
• Fusion Tag: C-Fc
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for CD31/PECAM-1 recombinant protein

Protein Construction: Recombinant Human PECAM-1 is produced by our mammalian expression system and the target gene encoding Gln28-Lys601 is expressed with a Fc tag at the C-terminus.

Background: Semaphorin-4G is the least characterized of the seven known Class 4 transmembrane semaphorin glycoproteins. Class 4 semaphorins play multiple roles in cell attraction or repulsion, such as development of nerve pathways in the brain, promoting or inhibiting proliferation, in some cases organizing immune cell interactions. Semaphorin-4G can be expressed early in development in the central and peripheral nervous systems and in sensory ograns, such as cochlea, olfactory epithelium, vomeronasal organ and retina. In adults, Semaphorin-4G can be found in liver,kidney and brain. The human Semaphorin-4G precursor consists of a 17 amino acids signal sequence, a 658 amino acids extracellular domain, a 21 amino acids transmembrane domain, a 142 amino acids cytoplasmic domain with one Ser/Thr phosphorylation site.

NCBI and Uniprot Product Information

• NCBI GI #: 118763944
• NCBI GeneID: 57715
• UniProt Accession #: Q9NTN9
• Molecular Weight: Molecular Mass: 91.6kDa; Actual Protein Molecular Mass: 110-130kDa
• NCBI Official Full Name: SEMA4G protein
• NCBI Official Synonym Full Names: semaphorin 4G
• NCBI Official Symbol: SEMA4G
• NCBI Protein Information: semaphorin-4G
• UniProt Protein Name: Semaphorin-4G
• UniProt Gene Name: SEMA4G
• UniProt Synonym Gene Names: KIAA1619

NCBI Description

Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Uniprot Description

Cell surface receptor for PLXNB2. May play a role in axon guidance ().