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12 results for "p70S6K inhibitor" - showing 1-12
p70S6K Kinase, Polyclonal Antibody (Cat# AAA194321)
Full Name
p70S6 Kinase Polyclonal Antibody
Gene Names
RPS6KB1; S6K1
Applications
Western Blot
Pricing
$520/0.1 mg | $2,290/5x0.1 mg
Structure
Baricitinib, Inhibitor (Cat# AAA576687)
Full Name
Baricitinib (LY3009104, INCB028050)
Purity
98.9%
Pricing
$185/2 mg | $195/5 mg | $205/10 mg | $230/25 mg | $245/50 mg | $270/100 mg | $195/1 mL (in DMSO) | $950/5x100 mg
Testing Data
(GSK429286A is a cell-permeable, selective Rho-associated kinase (ROCK) inhibitor with an IC50 of 14 nM. Not only was GSK429286A a potent ROCK1 inhibitor, but GSK429286A also possessed exciting selectivity (30-fold) against a panel of 33 kinases, including RSK1 (IC50 = 3.1 uM) and p70S6K (Ic50 = 2.85 uM). ROCKs are serine/threonine specific protein kinases which play a crucial role in organization of the actin cytoskeleton. ROCK inhibitors have been found to prevent apoptosis, as well as to enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency. Because of GSK429286A)
Testing Data
(PP121 is a multitargeted dual receptor tyrosine kinases inhibitor with IC50 of 0.052, 1.4, 0.15, 1.1, 0.06, 0.01and 0.002 uM for p110alpha, p110beta, p110delta, p110gamma, DNA-PK, mTOR and PDGFR, respectively. PP121 also inhibits Abl, Hck, Src,Src(T338I), VEGFR2, EGFR EphB4 with IC50 of 0.018, 0.008, 0.014, 0.22, 0.012, 0.26, 0.19 uM, respectively. PP121 exhibits no significant effect on receptor serine/threonine kinases (RSTKs). PP121 blocks the proliferation of tumor cells by direct inhibition of PI 3-K, mTOR, Src and the VEGF receptor. PP121 achieves its dual potency by targeting a residue (Glu310 in Src) that has been structurally conserved between kinase families. PP121 potently and dose-dependently blocked the phosphorylation of Akt, p70S6K and S6 in these cells. [1])
Chemical Structure
GSK-25, Inhibitor (Cat# AAA5750590)
Full Name
GSK-25
Purity
98.00%
Pricing
$205/2 mg | $240/5 mg | $310/25 mg | $710/100 mg | $2,930/5x100 mg
Structure
PI3K/mTOR-2, Inhibitor (Cat# AAA5753690)
Full Name
PI3K/mTOR Inhibitor-2
Purity
98.00%
Pricing
$425/5 mg | $600/10 mg | $1,525/50 mg | $2,035/100 mg | $455/1mL*10mM (in DMSO) | $8,870/5x100 mg
Structure
3BDO, Inhibitor (Cat# AAA5754430)
Full Name
3BDO
Purity
98.00%
Pricing
$210/5 mg | $240/10 mg | $330/25 mg | $215/1mL*10mM (in DMSO) | $1,180/5x25 mg
Coumestrol, Inhibitor (Cat# AAA5764542)
Full Name
Coumestrol
Purity
98.00%
Pricing
$295/1 mg | $440/5 mg | $650/10 mg | $1,065/25 mg | $1,525/50 mg | $450/1 mL (in DMSO) | $6,605/5x50 mg
Structure
Dactolisib, Inhibitor (Cat# AAA3606565)
Full Name
Dactolisib
Purity
>98% (HPLC)
Pricing
$200/50 mg | $205/100 mg | $240/200 mg | $795/5x200 mg
LY-2584702 hydrochloride, Inhibitor (Cat# AAA3845846)
Full Name
LY-2584702 hydrochloride
Purity
>98%
Pricing
$420/1 mg | $1,155/5 mg | $1,900/10 mg | $8,485/5x10 mg
Chemical Structure
LY-2584702, Inhibitor (Cat# AAA3840248)
Full Name
LY-2584702
Purity
>98%
Pricing
$160/5 mg | $210/10 mg | $395/25 mg | $1,730/5x25 mg
Structure
CYC-116, Inhibitor (Cat# AAA3605650)
Full Name
CYC-116
Purity
>98% (HPLC)
Pricing
$210/10 mg | $275/25 mg | $345/50 mg | $520/100 mg | $830/200 mg | $3,445/5x200 mg
