Mouse anti-Human MTUS1 Monoclonal Antibody | anti-MTUS1 antibody

MTUS1 (Microtubule-associated Tumor Suppressor 1, AT2 Receptor-binding Protein, Angiotensin-II Type 2 Receptor-interacting Protein, Mitochondrial Tumor Suppressor 1, ATBP, ATIP, GK1, KIAA1288, MTSG1, DKFZp586D1519, DKFZp686F20243, FLJ14295, KIAA1288)

Cat. Num. AAA645634

• Gene Names: MTUS1; ATBP; ATIP; ICIS; MP44; MTSG1
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: MTUS1; Monoclonal Antibody; MTUS1 (Microtubule-associated Tumor Suppressor 1; AT2 Receptor-binding Protein; Angiotensin-II Type 2 Receptor-interacting Protein; Mitochondrial Tumor Suppressor 1; ATBP; ATIP; GK1; KIAA1288; MTSG1; DKFZp586D1519; DKFZp686F20243; FLJ14295; KIAA1288); Anti -MTUS1 (Microtubule-associated Tumor Suppressor 1; anti-MTUS1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: 1C7
• Specificity: Recognizes human MTUS1.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MQLQEQFDNLNAAHETSKLEIEASHSEKLELLTKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMGKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQSPRNSGSFPSPSISPR

• Applicable Applications for anti-MTUS1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.
• Immunogen: Full length recombinant corresponding to aa1-241 from human MTUS1 (AAH33842) with GST tag. MW of the GST tag alone is 26kD.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot detection against Immunogen (52.51kD).)

Western Blot (WB)

(MTUS1 monoclonal antibody. Western Blot analysis of MTUS1 expression in human colon.)

Testing Data

(Detection limit for recombinant GST tagged MTUS1 is ~0.3ng/ml as a capture antibody.)

Related Product Information for anti-MTUS1 antibody

Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.

Product Categories/Family for anti-MTUS1 antibody

Antibodies; Abs to Tumor Suppressors

NCBI and Uniprot Product Information

• NCBI GI #: 50348617
• NCBI GeneID: 57509
• NCBI Accession #: NP_001001925.1
• NCBI GenBank Nucleotide #: NM_001001925.2
• UniProt Accession #: Q9ULD2; Q63HJ6; Q659F4; Q6PK49; Q6URW7; Q8N4M6; A8K135; B2RBJ6; B3KWJ9; B4DH03; B9EGA1; D3DSP8
• Molecular Weight: 141,397 Da
• NCBI Official Full Name: microtubule-associated tumor suppressor 1 isoform 2
• NCBI Official Synonym Full Names: microtubule associated tumor suppressor 1
• NCBI Official Symbol: MTUS1
• NCBI Official Synonym Symbols: ATBP; ATIP; ICIS; MP44; MTSG1
• NCBI Protein Information: microtubule-associated tumor suppressor 1; AT2R binding protein; transcription factor MTSG1; AT2 receptor-binding protein; AT2 receptor-interacting protein; erythroid differentiation-related; mitochondrial tumor suppressor gene 1; angiotensin-II type 2 receptor-interacting protein
• UniProt Protein Name: Microtubule-associated tumor suppressor 1
• Protein Family: Microtubule-associated tumor suppressor
• UniProt Gene Name: MTUS1
• UniProt Synonym Gene Names: ATBP; ATIP; GK1; KIAA1288; MTSG1
• UniProt Entry Name: MTUS1_HUMAN

NCBI Description

This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. Ref.2 Ref.16

Subunit structure: Homodimer. Interacts with AGTR2. Interacts with PTPN6

By similarity. Isoform 1 associates with microtubules. Ref.3

Subcellular location: Mitochondrion. Golgi apparatus

By similarity. Cell membrane

By similarity. Nucleus

By similarity. Note: In neurons, translocates into the nucleus after treatment with angiotensin-II

By similarity. Ref.1 Ref.2 Ref.16Isoform 1: Cytoplasm › cytoskeleton › microtubule organizing center › centrosome. Cytoplasm › cytoskeleton › spindle. Note: Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis. Ref.1 Ref.2 Ref.16

Tissue specificity: Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain-specific, it is the major isoform in cerebellum and fetal brain. Ref.1 Ref.2 Ref.3 Ref.11 Ref.12 Ref.13 Ref.20

Induction: Isoform 1 is down-regulated in invasive breast carcinomas (at protein level). Ref.16

Involvement in disease: Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes.Note: The gene represented in this entry may be involved in disease pathogenesis. Ref.19

Sequence similarities: Belongs to the MTUS1 family.

Sequence caution: The sequence AAH07328.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.The sequence AAH33842.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB14894.1 differs from that shown. Reason: Erroneous initiation.