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11 results for "mTORC1 mTORC2 inhibitor" - showing 1-11
Structure
Torin 1, Inhibitor (Cat# AAA578620)
Full Name
Torin 1
Purity
98.3%
Pricing
$195/2 mg | $215/5 mg | $250/10 mg | $390/25 mg | $525/50 mg | $785/100 mg | $3,260/5x100 mg
Structure
XL388, Inhibitor (Cat# AAA578605)
Full Name
XL388
Purity
99.4%
Pricing
$205/1 mg | $240/2 mg | $295/5 mg | $350/10 mg | $615/25 mg | $870/50 mg | $1,145/100 mg | $295/1 mL (in DMSO) | $4,880/5x100 mg
Testing Data
(PI-103 is a potent, cell-permeable, ATP-competitive PI3K family members inhibitor with IC50 of 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110alpha, mTORC1, PI3-KC2beta, p110delta, mTORC2, p110beta, and p110gamma, respectively. It shows little activity against a wide array of protein kinases at 10 mM. It blocks glioma proliferation by blocking the PI 3-K/Akt pathway in vitro and in vivo. PI-103 was essentially cytostatic for cell lines and induced cell cycle arrest in the G1 phase. In blast cells, PI-103 inhibited leukemic proliferation, the clonogenicity of leukemic progenitors and induced mitochondrial apoptosis, especially in the compartment containing leukemic stem cells. PI-103 had additive proapoptotic effects with etoposide in blast cells and in immature leukemic cells. [1][2][3])
Structure
Torin1, Inhibitor (Cat# AAA3600848)
Full Name
Torin1
Purity
>98% (HPLC)
Pricing
$190/2 mg | $210/5 mg | $245/10 mg | $370/25 mg | $485/50 mg | $715/100 mg | $2,945/5x100 mg
Structure
PP 242, Inhibitor (Cat# AAA3600346)
Full Name
PP 242
Purity
>98% (HPLC)
Pricing
$200/5 mg | $210/10 mg | $245/25 mg | $260/50 mg | $330/100 mg | $415/200 mg | $1,590/5x200 mg
Structure
Palomid 529, Inhibitor (Cat# AAA3607652)
Full Name
Palomid 529
Purity
>98% (HPLC)
Pricing
$190/2 mg | $210/5 mg | $245/10 mg | $340/25 mg | $470/50 mg | $745/100 mg | $3,065/5x100 mg
Structure
OSI-027, Inhibitor (Cat# AAA3606705)
Full Name
OSI-027
Purity
>98% (HPLC)
Pricing
$230/5 mg | $305/10 mg | $580/50 mg | $2,305/5x50 mg
Structure
PQR-530, Inhibitor (Cat# AAA5755404)
Full Name
PQR-530
Purity
98.00%
Pricing
$265/2 mg | $310/5 mg | $390/10 mg | $620/25 mg | $890/50 mg | $1,245/100 mg | $5,325/5x100 mg
FT-1518, Inhibitor (Cat# AAA3843687)
Full Name
FT-1518
Purity
>98%
Pricing
$420/1 mg | $1,155/5 mg | $1,900/10 mg | $8,485/5x10 mg
Structure
KU-0063794, Inhibitor (Cat# AAA3606714)
Full Name
KU-0063794
Purity
>98% (HPLC)
Pricing
$200/5 mg | $210/10 mg | $250/25 mg | $335/50 mg | $500/100 mg | $1,975/5x100 mg
Structure
XL388, Inhibitor (Cat# AAA3607213)
Full Name
XL388
Purity
>98% (HPLC)
Pricing
$235/2 mg | $280/5 mg | $330/10 mg | $570/25 mg | $800/50 mg | $1,050/100 mg | $4,430/5x100 mg
