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22 results for "BRAF inhibitor" - showing 1-22
Testing Data
(PLX4032 (Vemurafenib) is a highly selective inhibitor of BRAF kinase activity, with an IC50 of 44 nmol/L against V600E-mutant BRAF. [1] BRAFV600E cancer-causing mutation occurs in most melanomas and about eight percent of all solid tumors. [2] BRAF mutant melanoma cell strains were highly sensitive to PLX4032 with IC50 in the nM range (60 -450 nM), whereas BRAF wild-type cells were resistant, with IC50 2.4 uM or above. [3])
PLX-4032, Inhibitor (Cat# AAA8506253)
Full Name
PLX-4032 (RG7204)
Pricing
$440/10 mg | $1,940/5x10 mg
Testing Data
(GDC-0879 is a highly selective, novel potent, orally bioavailable B-Raf inhibitor in various in vitro and cell-based assays with an IC50 estimate of 0.13 nM against purified B-Raf V600E enzyme and a cellular pERK IC50 of 63 nM in the MALME-3M cell line. [1]For this compound, subnanomolar enzyme potency translated into very effective reduction of cellular viability of BRAF-mutant Malme3M cells (EC50 values were 0.75 umol/L for GDC-0879). [1]In GDC-0879-treated mice, both cell line- and patient-derived BRAFV600E tumors exhibited stronger and more sustained pharmacodynamic inhibition (>90% for 8 hours) and improved survival compared with mutant KRAS-expressing tumors.[2])
GDC-0879, Inhibitor (Cat# AAA8506531)
Full Name
GDC-0879
Purity
>99%
Pricing
$380/2 mg | $1,665/5x2 mg
Chemical Structure
BRAF inhibitor, Inhibitor (Cat# AAA130035)
Full Name
BRAF inhibitor
Purity
98%
Pricing
$1,055/100 mg | $2,765/500 mg
Immunohistochemistry (IHC)
(At 1/100 staining Human kidney cancer and adjacent normal tissues by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the primary antibody at 4 degree C overnight. An HRP conjugated anti-Rabbit antibody was used as the secondary antibody.)
C-RAF, Polyclonal Antibody (Cat# AAA9613037)
Full Name
Phospho-C-RAF (Thr269) Antibody
Gene Names
RAF1; NS5; CRAF; Raf-1; c-Raf
Reactivity
Human, Mouse, Rat
Applications
IHC, EIA
Purity
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
Pricing
$305/0.1 mL | $365/0.2 mL | $1,495/5x0.2 mL
Western Blot (WB)
(Western blot analysis of C-RAF (Phospho-Tyr340) using Jurkat whole cell lysates.-/+ means absence or presence of N peptide（non-phospho peptide) and P peptide(phospho peptide).)
C-RAF, Polyclonal Antibody (Cat# AAA9614221)
Full Name
Phospho-C-RAF (Tyr340) Antibody
Gene Names
RAF1; NS5; CRAF; Raf-1; c-Raf
Reactivity
Human, Mouse, Rat
Predicted Reactivity: Pig (100%), Bovine (100%), Sheep (100%), Rabbit (100%), Dog (100%), Chicken (100%), Xenopus (100%)
Predicted Reactivity: Pig (100%), Bovine (100%), Sheep (100%), Rabbit (100%), Dog (100%), Chicken (100%), Xenopus (100%)
Applications
WB, IF, ICC, EIA
Purity
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
Pricing
$245/0.05 mL | $310/0.1 mL | $370/0.2 mL | $1,605/5x0.2 mL
KO-947, Inhibitor (Cat# AAA5764263)
Full Name
KO-947
Purity
98.00%
Pricing
$265/5 mg | $335/10 mg | $515/25 mg | $830/50 mg | $1,415/100 mg | $6,095/5x100 mg
Lifirafenib, Inhibitor (Cat# AAA5756800)
Full Name
Lifirafenib
Purity
98.00%
Pricing
$250/5 mg | $450/25 mg | $1,745/5x25 mg
Structure
LXH254, Inhibitor (Cat# AAA5753435)
Full Name
LXH254
Purity
98.00%
Pricing
$230/1 mg | $310/5 mg | $395/10 mg | $600/25 mg | $960/50 mg | $1,370/100 mg | $400/1 mL (in DMSO) | $5,900/5x100 mg
Structure
Ravoxertinib hydrochloride, Inhibitor (Cat# AAA5754898)
Full Name
Ravoxertinib hydrochloride
Purity
98.00%
Pricing
$235/2 mg | $275/5 mg | $355/10 mg | $765/50 mg | $280/1mL*10mM (in DMSO) | $3,160/5x50 mg
C-RAF, Polyclonal Antibody (Cat# AAA9613945)
Full Name
C-RAF Antibody
Gene Names
RAF1; NS5; CRAF; Raf-1; c-Raf
Reactivity
Human
Applications
EIA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin
Pricing
$260/0.1 mL | $305/0.2 mL | $1,220/5x0.2 mL
C-RAF, Polyclonal Antibody (Cat# AAA9612992)
Full Name
Phospho-C-RAF (Ser642) Antibody
Gene Names
RAF1; NS5; CRAF; Raf-1; c-Raf
Reactivity
Human, Mouse, Rat
Applications
EIA
Purity
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
Pricing
$305/0.1 mL | $365/0.2 mL | $1,495/5x0.2 mL
Immunofluorescence (IF)/Immunocytochemistry (ICC)
(Staining Hela cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25 degree C. Samples were then incubated with primary Ab(AF6969) and mouse anti-beta tubulin Ab(T0023) for 1 hour at 37 degree C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) Ab(Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) Ab(Green) were used as the secondary antibody.The nuclear counter stain is DAPI(blue).)
C-RAF, Polyclonal Antibody (Cat# AAA9613990)
Full Name
C-RAF Antibody
Gene Names
RAF1; NS5; CRAF; Raf-1; c-Raf
Reactivity
Human
Applications
IF, ICC, EIA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin
Pricing
$260/0.1 mL | $305/0.2 mL | $1,220/5x0.2 mL
Structure
BRAF inhibitor 13, Inhibitor (Cat# AAA3600357)
Full Name
BRAF inhibitor 13
Purity
>98% (HPLC)
Pricing
$200/2 mg | $230/5 mg | $280/10 mg | $370/25 mg | $1,380/5x25 mg
Structure
BRAF, Inhibitor (Cat# AAA5752821)
Full Name
BRAF inhibitor
Purity
98.00%
Pricing
$300/10 mg | $575/50 mg | $315/1mL*10mM (in DMSO) | $2,285/5x50 mg
Structure
PLX-8394, Inhibitor (Cat# AAA3601639)
Full Name
PLX-8394
Purity
>98% (HPLC)
Pricing
$230/5 mg | $280/10 mg | $375/25 mg | $580/50 mg | $755/100 mg | $3,130/5x100 mg
Structure
Regorafenib Hydrochloride, Inhibitor (Cat# AAA5759205)
Full Name
Regorafenib Hydrochloride
Purity
100.00%
Pricing
$190/5 mg | $205/10 mg | $240/50 mg | $285/100 mg | $205/1 mL (in DMSO) | $1,020/5x100 mg
Structure
Chemical Structure
BRAF, Inhibitor (Cat# AAA386709)
Full Name
BRAF inhibitor
Purity
>98%
Pricing
$180/5 mg | $260/10 mg | $455/25 mg | $2,000/5x25 mg
Chemical Structure
AZ304, Inhibitor (Cat# AAA3842200)
Full Name
AZ304
Purity
>98%
Pricing
$190/5 mg | $285/10 mg | $915/50 mg | $1,435/100 mg | $6,400/5x100 mg
Chemical Structure
Lifirafenib, Inhibitor (Cat# AAA3841821)
Full Name
Lifirafenib (BGB-283)
Purity
>98%
Pricing
$170/5 mg | $235/10 mg | $605/50 mg | $2,675/5x50 mg
Chemical Structure
ERK-IN-3, Inhibitor (Cat# AAA5765240)
Full Name
ERK-IN-3
Purity
0.9976
Pricing
$240/2 mg | $275/5 mg | $355/10 mg | $620/25 mg | $980/50 mg | $4,140/5x50 mg
BI-882370, Inhibitor (Cat# AAA5764306)
Full Name
BI-882370
Purity
98.00%
Pricing
$205/2 mg | $225/5 mg | $270/10 mg | $365/25 mg | $560/50 mg | $885/100 mg | $3,705/5x100 mg
