Structure

Regorafenib Hydrochloride, Inhibitor

Regorafenib Hydrochloride

Purity

100.00%

Synonyms

Regorafenib Hydrochloride; BAY73-4506 hydrochloride; inhibitor

Ordering
Cat. Num. AAA5759205 For Research Use Only!

Purity/Purification

100.00%

Form/Format

Solid. Powder

Solubility

DMSO: 5.6mg/mL (10.78mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C21H16Cl2F4N4O3

SMILES

Cl.CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c(F)c2)ccn1

CAS Number

835621-07-3

Target & IC50

VEGFR1: ic50 13nM
VEGFR2: ic50 4.2nM
VEGFR3: ic50 46nM
PDGFRbeta: ic50 22nM
Braf: ic50 28nM
BRafV600E: ic50 19nM
Raf-1: ic50 2.5nM

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Structure

Related Product Information for Regorafenib Hydrochloride, inhibitor

Regorafenib Hydrochloride is a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity

Product Categories/Family for Regorafenib Hydrochloride, inhibitor

Angiogenesis; VEGFR; Tyrosine Kinase/Adaptors; Apoptosis; MAPK

References

Wilhelm SM, et al. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer, 2011, 129(1), 245-255.
Wilhelm SM, et al. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer, 2011, 129(1), 245-255.
Carr BI, et al. Fluoro-Sorafenib (Regorafenib) effects on hepatoma cells: growth inhibition, quiescence, and recovery. J Cell Physiol, 2013, 228(2), 292-297.
Carr BI, et al. Fluoro-Sorafenib (Regorafenib) effects on hepatoma cells: growth inhibition, quiescence, and recovery. J Cell Physiol, 2013, 228(2), 292-297.

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Product Notes

The Regorafenib Hydrochloride (Catalog #AAA5759205) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Regorafenib Hydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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Regorafenib Hydrochloride, Inhibitor