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21 results for " c Met VEGFR2" - showing 1-21
vascular endothelial growth factor, Active Protein (Cat# AAA400074)
Full Name
Human vascular endothelial growth factor (VEGF-165)
Gene Names
VEGFA; VPF; VEGF; MVCD1
Purity
Greater than 98.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Anion-exchange FPLC.
(c) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel.
(d) Gel filtration chromatography under non denaturative conditions
(a) Analysis by RP-HPLC.
(b) Anion-exchange FPLC.
(c) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel.
(d) Gel filtration chromatography under non denaturative conditions
Pricing
$200/0.01 mg | $360/0.05 mg | $460/0.1 mg | $2,700/1 mg | $11,945/5x1 mg
Chemical Structure
Foretinib (GSK1363089, XL880), Inhibitor (Cat# AAA384812)
Full Name
Foretinib (GSK1363089, XL880)
Purity
>98%
Pricing
$125/5 mg | $200/25 mg | $300/50 mg | $465/100 mg | $150/1 mL (in DMSO) | $2,050/5x100 mg
Structure
MGCD-265, Inhibitor (Cat# AAA578901)
Full Name
MGCD-265
Purity
98.1%
Pricing
$215/2 mg | $250/5 mg | $335/10 mg | $520/25 mg | $775/50 mg | $275/1 mL (in DMSO) | $3,210/5x50 mg
Testing Data
(Foretinib (GSK1363089, XL880) is a novel MET and VEGFR2/KDR kinases inhibitor with an IC50 of 0.4 and 0.8 nM for MET and KDR, respectively. Foretinib (GSK1363089, XL880) inhibits HGF receptor family tyrosine kinases with an IC50 of 3 nM for Ron. Foretinib (GSK1363089, XL880) also inhibits KDR, Flt-1, and Flt-4 with IC50 of 0.9, 6.8 and 2.8 nM, respectively. In addition, EXEL-2880 inhibits members of the platelet-derived growth factor receptor family and the angiopoietin-1 receptor Tie-2. Foretinib (GSK1363089, XL880) exhibits modest activity against fibroblast growth factor receptor 1 and epidermal growth factor receptor and is inactive against 50 serine/threonine kinases, including cyclin-dependent kinases and protein kinase C isoforms. To delineate the cellular effect of foretinib (GSK1363089, XL880), VEGF- induced extracellular signal-regulated kinase phosphorylation was used to assess the effect of the compound on phosphorylation of KDR in human umbilical vein endothelial cells that resulted in an IC50 of 16 nM. Foretinib(GSK1363089, XL880) is the 1st orally available small molecule inhibitor of Met to enter the clinic and appears to be generally well tolerated. Anti-tumor activity has been observed and Foretinib may represent an active treatment option for patients with papillary renal-cell carcinoma. [1])
Foretinib, Inhibitor (Cat# AAA8506342)
Full Name
Foretinib (GSK1363089, XL880)
Purity
>99%
Pricing
$440/5 mg | $1,940/5x5 mg
Structure
Golvatinib, Inhibitor (Cat# AAA579058)
Full Name
Golvatinib (E7050)
Purity
98.24%
Pricing
$175/1 mg | $185/2 mg | $210/5 mg | $235/10 mg | $295/25 mg | $330/50 mg | $480/100 mg | $230/1 mL (in DMSO) | $1,900/5x100 mg
CP-724714, Inhibitor (Cat# AAA579919)
Full Name
CP-724714
Purity
98.82%
Pricing
$205/2 mg | $235/5 mg | $295/10 mg | $430/25 mg | $595/50 mg | $835/100 mg | $235/1 mL (in DMSO) | $3,495/5x100 mg
SDS-Page
VEGFR2/KDR, Recombinant Protein (Cat# AAA8123084)
Full Name
VEGFR2/KDR Protein, Mouse, Recombinant (His Tag)
Gene Names
Kdr; Flk1; Ly73; Flk-1; Krd-1; VEGFR2; VEGFR-2; sVEGFR-2; 6130401C07
Purity
>90% as determined by SDS-PAGE
Pricing
$395/0.1 mg | $2,175/1 mg | $9,625/5x1 mg
Structure
Foretinib, Inhibitor (Cat# AAA3606162)
Full Name
Foretinib
Purity
>98% (HPLC)
Pricing
$185/5 mg | $200/10 mg | $235/25 mg | $305/50 mg | $405/100 mg | $1,520/5x100 mg
Cabozantinib hydrochloride, Inhibitor (Cat# AAA5751609)
Full Name
Cabozantinib hydrochloride (849217-68-1 (free base))
Purity
98.00%
Pricing
$195/2 mg | $210/5 mg | $240/10 mg | $300/25 mg | $375/50 mg | $480/100 mg | $705/200 mg | $2,905/5x200 mg
Structure
BMS-2, Inhibitor (Cat# AAA5759133)
Full Name
BMS-2
Purity
99.70%
Pricing
$240/1 mg | $330/5 mg | $445/10 mg | $730/25 mg | $3,020/5x25 mg
Structure
BMS-2, Inhibitor (Cat# AAA3611647)
Full Name
BMS-2
Purity
>98% (HPLC)
Pricing
$315/5 mg | $405/10 mg | $675/25 mg | $2,745/5x25 mg
Structure
Cabozantinib (S-malate), Inhibitor (Cat# AAA3600498)
Full Name
Cabozantinib (S-malate)
Purity
>98% (HPLC)
Pricing
$200/5 mg | $210/10 mg | $235/50 mg | $265/100 mg | $355/200 mg | $1,300/5x200 mg
Structure
MGCD-265, Inhibitor (Cat# AAA3606356)
Full Name
MGCD-265
Purity
>98% (HPLC)
Pricing
$210/2 mg | $245/5 mg | $315/10 mg | $480/25 mg | $710/50 mg | $2,900/5x50 mg
VEGFR2/KDR, Cell Lysate (Cat# AAA8116982)
Full Name
Mouse VEGFR2/KDR HEK293 Overexpression Lysate
Gene Names
Kdr; Flk1; Ly73; Flk-1; Krd-1; VEGFR2; VEGFR-2; sVEGFR-2; 6130401C07
Applications
WB
Pricing
$280/0.3 mg | $1,205/5x0.3 mg
VEGFR2/KDR, Cell Lysate (Cat# AAA8113389)
Full Name
Human VEGFR2/KDR HEK293 Overexpression Lysate
Gene Names
KDR; FLK1; CD309; VEGFR; VEGFR2
Applications
WB
Pricing
$280/0.3 mg | $1,205/5x0.3 mg
Structure
BMS-794833, Inhibitor (Cat# AAA3600589)
Full Name
BMS-794833
Purity
>98% (HPLC)
Pricing
$190/2 mg | $230/5 mg | $275/10 mg | $395/25 mg | $620/50 mg | $2,495/5x50 mg
Cabozantinib, Inhibitor (Cat# AAA3606163)
Full Name
Cabozantinib
Purity
>98% (HPLC)
Pricing
$200/5 mg | $205/10 mg | $215/50 mg | $250/100 mg | $315/200 mg | $1,125/5x200 mg
VEGFR2/KDR, Cell Lysate (Cat# AAA8117398)
Full Name
Rat VEGFR2/KDR HEK293 Overexpression Lysate
Gene Names
Kdr; Vegfr-2
Applications
WB
Pricing
$280/0.3 mg | $1,205/5x0.3 mg
Chemical Structure
BMS-817378, Inhibitor (Cat# AAA3841193)
Full Name
BMS-817378
Purity
>98%
Pricing
$180/5 mg | $260/10 mg | $455/25 mg | $2,000/5x25 mg
Structure
E-7050, Inhibitor (Cat# AAA3606641)
Full Name
E-7050
Purity
>98% (HPLC)
Pricing
$230/5 mg | $250/10 mg | $330/25 mg | $480/50 mg | $1,870/5x50 mg
VEGFR2/KDR, Cell Lysate (Cat# AAA8113385)
Full Name
Human VEGFR2/KDR HEK293 Overexpression Lysate
Gene Names
KDR; FLK1; CD309; VEGFR; VEGFR2
Applications
WB
Pricing
$280/0.3 mg | $1,205/5x0.3 mg
