Cabozantinib, Inhibitor
Cabozantinib
Purity
>98% (HPLC)
Synonyms
Cabozantinib; XL184; BMS-907351; XL-184; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=30mg/mL
Target
VEGFR
Receptor
AXL; c-Met; Kit; VEGFR2/KDR; VEGFR3/FLT4; VEGFR2; MET; MET (Y1248H); RET; FLT3
Chemical Name
1, 1-Cyclopropanedicarboxamide, N'-[4-[(6, 7-dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)
SMILES
COC1=CC2=NC=CC(OC3=CC=C(C=C3)N(C(=O)C3(CC3)C(N)=O)C3=CC=C(F)C=C3)=C2C=C1OC
Molecular Formula
C28H24FN3O5
CAS Number
849217-68-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Related Product Information for Cabozantinib, inhibitor
Cabozantinib (XL184, BMS-907351) is a potent multi-kinase inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50 of 0.035, 1.3, 4.6, 7 and 11.3nM, respectively; eliminates tumor vasculature, reduces pericytes and empty basement membrane sleeves, causes widespread intratumoral hypoxia and tumor cell apoptosis, and slows regrowth of the tumor vasculature, also decreases invasiveness of primary tumors and reduces metastasis in pancreatic islet cancer; exerts marked anti-MPNST effects in vitro and in vivo.Kidney Cancer Approved
Product Categories/Family for Cabozantinib, inhibitor
References
1. You WK, et al. Cancer Res. 2011 Jul 15; 71 (14):4758-68.
2. Durante C, et al. Expert Opin Investig Drugs. 2011 Mar; 20 (3):407-413.
3. Torres KE, et al. Clin Cancer Res. 2011 Jun 15; 17 (12):3943-55.
4. Kurzrock R, et al. J Clin Oncol. 2011 Jul 1; 29 (19):2660-6.
2. Durante C, et al. Expert Opin Investig Drugs. 2011 Mar; 20 (3):407-413.
3. Torres KE, et al. Clin Cancer Res. 2011 Jun 15; 17 (12):3943-55.
4. Kurzrock R, et al. J Clin Oncol. 2011 Jul 1; 29 (19):2660-6.
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Product Notes
The Cabozantinib (Catalog #AAA3606163) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Cabozantinib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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