SDS-PAGE
Uteroglobin / SCGB1A1 Recombinant Protein | SCGB1A1 recombinant protein
Recombinant Mouse Uteroglobin / SCGB1A1 Protein (His tag)
Gene Names
Scgb1a1; UG; UGB; Utg; CC10; CC16; CCSP; PCB-BP
Purity
> 88 % as determined by SDS-PAGE
Synonyms
Uteroglobin / SCGB1A1; Recombinant Mouse Uteroglobin / SCGB1A1 Protein (His tag); CC10; CC16; CCSP; PCB-BP; UG; UGB; Utg; SCGB1A1 recombinant protein
Host
Human Cells
Purity/Purification
> 88 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
96
Application Notes
The recombinant mouse SCGB1A1 consists of 86 amino acids and has a predicted molecular mass of 9.8 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm SCGB1A1 is approximately 12 kDa.
Predicted N Terminal
Asp 22
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for SCGB1A1 recombinant protein
Background: Uteroglobin (UG), also known as Secretoglobin 1A member 1 (SCGB1A1), Blastokinin, Clara cell secretor protein (CCSP) or Clara cell-specific 10-kDa protein (CC10), is the founding member of the secretoglobin family of small, secreted, disulfide-bridged dimeric proteins found only in mammals. This protein is mainly expressed in lung, with anti-inflammatory/immunomodulatory properties. Previous in vitro studies demonstrated that CCAAT/enhancer-binding proteins (C/EBPs) are the major transcription factors for the regulation of SCGB1A1 gene expression, whereas FOXA1 had a minimum effect on the transcription. Uteroglobin is a multifunctional protein with antiinflammatory/immunomodulatory properties. Uteroglobin inhibits soluble phospholipase A (2) activity and binds and perhaps sequesters hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids, and prostaglandins. In addition to its antiinflammatory activities, Uteroglobin manifests antichemotactic, antiallergic, antitumorigenic, and embryonic growth-stimulatory activities. The tissue-specific expression of the Uteroglobin gene is regulated by several steroid hormones, although a nonsteroid hormone, prolactin, further augments its expression in the uterus. Based on its anti-inflammatory and antiallergic properties, Uteroglobin is a potential drug target. The mechanism of Uteroglobin action is likely to be even more complex as it also functions via a putative receptor-mediated pathway.
Description: A DNA sequence encoding the mouse SCGB1A1 (Q06318) (Met 1-Phe 96) was expressed, with a polyhistidine tag at the C-terminus.
Description: A DNA sequence encoding the mouse SCGB1A1 (Q06318) (Met 1-Phe 96) was expressed, with a polyhistidine tag at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
10,519 Da
NCBI Official Full Name
uteroglobin
NCBI Official Synonym Full Names
secretoglobin, family 1A, member 1 (uteroglobin)
NCBI Official Symbol
Scgb1a1
NCBI Official Synonym Symbols
UG; UGB; Utg; CC10; CC16; CCSP; PCB-BP
NCBI Protein Information
uteroglobin
UniProt Protein Name
Uteroglobin
Protein Family
UniProt Gene Name
Scgb1a1
UniProt Synonym Gene Names
Cc10; Ugb; Utg; CCPBP; CC10
Uniprot Description
SCGB1A1: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2. Belongs to the secretoglobin family.
Protein type: Cell cycle regulation; Inhibitor; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19|19 A
Cellular Component: cytoplasm; endoplasmic reticulum; extracellular space; intracellular; nuclear envelope; rough endoplasmic reticulum; secretory granule
Biological Process: negative regulation of interferon-gamma production; negative regulation of interleukin-13 production; negative regulation of interleukin-4 production; negative regulation of interleukin-5 production; negative regulation of T cell proliferation; negative regulation of transcription from RNA polymerase II promoter; regulation of inflammatory response; regulation of mRNA stability; response to cytokine stimulus
Research Articles on SCGB1A1
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Product Notes
The SCGB1A1 scgb1a1 (Catalog #AAA2547053) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant mouse SCGB1A1 consists of 86 amino acids and has a predicted molecular mass of 9.8 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm SCGB1A1 is approximately 12 kDa. Researchers should empirically determine the suitability of the SCGB1A1 scgb1a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Uteroglobin / SCGB1A1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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