Rabbit anti-Human Uteroglobin Polyclonal Antibody | anti-SCGB1A1 antibody

Anti-Uteroglobin Antibody, Rabbit Polyclonal

Cat. Num. AAA8103982

• Gene Names: SCGB1A1; UGB; UP1; CC10; CC16; CCSP; UP-1; CCPBP
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: Uteroglobin; Polyclonal Antibody; Anti-Uteroglobin Antibody; Rabbit Polyclonal; Uteroglobin/SCGB1A1 Antibody; Rabbit PAb; Antigen Affinity Purified; secretoglobin; family 1A; member 1 (uteroglobin); Anti-CC10 Antibody; Anti-CC16 Antibody; Anti-CCPBP Antibody; Anti-CCSP Antibody; Anti-UGB Antibody; Anti-UP-1 Antibody; Anti-UP1 Antibody; anti-SCGB1A1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human Uteroglobin/SCGB1A1
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-SCGB1A1 antibody: ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: ELISA: 1:5000-1:10,000; IHC-P: 1:1000-1:10,000
• Immunogen: Recombinant Human Uteroglobin/SCGB1A1 Protein
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with purified, recombinant Human Uteroglobin/SCGB1A1 (rh Uteroglobin/SCGB1A1). Uteroglobin/SCGB1A1 specific IgG was purified by Human Uteroglobin/SCGB1A1 affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human SCGB1A1 in human lung with rabbit polyclonal antibody at 1:10000 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-SCGB1A1 antibody

Uteroglobin (UG), also known as Secretoglobin 1A member 1 (SCGB1A1), Blastokinin, Clara cell secretor protein (CCSP) or Clara cell-specific 10-kDa protein (CC10), is the founding member of the secretoglobin family of small, secreted, disulfide-bridged dimeric proteins found only in mammals. This protein is mainly expressed in lung, with anti-inflammatory/immunomodulatory properties. Previous in vitro studies demonstrated that CCAAT/enhancer-binding proteins (C/EBPs) are the major transcription factors for the regulation of SCGB1A1 gene expression, whereas FOXA1 had a minimum effect on the transcription. Uteroglobin is a multifunctional protein with antiinflammatory/immunomodulatory properties. Uteroglobin inhibits soluble phospholipase A(2) activity and binds and perhaps sequesters hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids, and prostaglandins. In addition to its antiinflammatory activities, Uteroglobin manifests antichemotactic, antiallergic, antitumorigenic, and embryonic growth-stimulatory activities. The tissue-specific expression of the Uteroglobin gene is regulated by several steroid hormones, although a nonsteroid hormone, prolactin, further augments its expression in the uterus. Based on its anti-inflammatory and antiallergic properties, Uteroglobin is a potential drug target. The mechanism of Uteroglobin action is likely to be even more complex as it also functions via a putative receptor-mediated pathway.

References

Mukherjee AB, et al. (1999). Uteroglobin: a novel cytokine? Cell Mol Life Sci. 55(5): 771-87.Klug J, et al. (2000). Uteroglobin/Clara cell 10-kDa family of proteins: nomenclature committee report. Ann. N. Y. Acad. Sci. 923: 348-54.Laukaitis CM, et al. (2005). Evolution of the secretoglobins: a genomic and proteomic view. Biological Journal of the Linnean Society. 84 (3): 493-501.Mukherjee AB, et al. (2007). Uteroglobin: a steroid-inducible immunomodulatory protein that founded the Secretoglobin superfamily. Endocr Rev. 28(7): 707-25.Kido T, et al. (2011). FOXA1 plays a role in regulating secretoglobin 1a1 expression in the absence of CCAAT/enhancer binding protein activities in lung in vivo. Am J Physiol Lung Cell Mol Physiol. 300(3): L441-52.

NCBI and Uniprot Product Information

• NCBI GI #: 112672
• NCBI GeneID: 7356
• UniProt Accession #: P11684; Q6FHH3; Q9UCM2; Q9UCM4; B2R5F2
• Molecular Weight: 91
• NCBI Official Full Name: Uteroglobin
• NCBI Official Synonym Full Names: secretoglobin, family 1A, member 1 (uteroglobin)
• NCBI Official Symbol: SCGB1A1
• NCBI Official Synonym Symbols: UGB; UP1; CC10; CC16; CCSP; UP-1; CCPBP
• NCBI Protein Information: uteroglobin; blastokinin; urine protein 1; urinary protein 1; clara cells 10 kDa secretory protein; clara cell phospholipid-binding protein
• UniProt Protein Name: Uteroglobin
• Protein Family: Uteroglobin
• UniProt Gene Name: SCGB1A1
• UniProt Synonym Gene Names: CC10; CCSP; UGB; CCPBP; CC10; UP-1; UP1; Urine protein 1
• UniProt Entry Name: UTER_HUMAN

NCBI Description

This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]

Uniprot Description

SCGB1A1: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2. Belongs to the secretoglobin family.

Protein type: Secreted; Cell cycle regulation; Secreted, signal peptide; Inhibitor

Chromosomal Location of Human Ortholog: 11q12.3

Cellular Component: extracellular space; rough endoplasmic reticulum; nuclear envelope; secretory granule

Molecular Function: protein binding; phospholipase A2 inhibitor activity

Biological Process: response to drug; negative regulation of interleukin-4 production; response to glucocorticoid stimulus; response to lipopolysaccharide; female pregnancy; negative regulation of transcription from RNA polymerase II promoter; signal transduction; regulation of mRNA stability; response to xenobiotic stimulus; response to silicon dioxide; negative regulation of interleukin-13 production; negative regulation of T cell proliferation; response to ozone; negative regulation of interferon-gamma production; response to cytokine stimulus; negative regulation of catalytic activity; regulation of inflammatory response; negative regulation of interleukin-5 production; embryo implantation

Disease: Asthma, Susceptibility To