Uteroglobin Recombinant Protein | SCGB1A1 recombinant protein

Uteroglobin Protein, Mouse, Recombinant (His Tag)

Cat. Num. AAA8122665

• Gene Names: Scgb1a1; UG; UGB; Utg; CC10; CC16; CCSP; PCB-BP
• Purity: >88% as determined by SDS-PAGE
• Synonyms: Uteroglobin; Uteroglobin Protein; Mouse; Recombinant (His Tag); Mouse Uteroglobin/SCGB1A1 Protein (His Tag); CC10 Protein; CC16 Protein; CCSP Protein; PCB-BP Protein; UG Protein; UGB Protein; Utg Protein; secretoglobin; family 1A; member 1 (uteroglobin); SCGB1A1 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >88% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Phe96

• Species: Mouse
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Asp 22
• Tag: C-His
• Protein Construction: A DNA sequence encoding the mouse SCGB1A1 (Q06318)(Met 1-Phe 96) was expressed, with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for SCGB1A1 recombinant protein

Background: Uteroglobin (UG), also known as Secretoglobin 1A member 1 (SCGB1A1), Blastokinin, Clara cell secretor protein (CCSP) or Clara cell-specific 10-kDa protein (CC10), is the founding member of the secretoglobin family of small, secreted, disulfide-bridged dimeric proteins found only in mammals. This protein is mainly expressed in lung, with anti-inflammatory/immunomodulatory properties. Previous in vitro studies demonstrated that CCAAT/enhancer-binding proteins (C/EBPs) are the major transcription factors for the regulation of SCGB1A1 gene expression, whereas FOXA1 had a minimum effect on the transcription. Uteroglobin is a multifunctional protein with antiinflammatory/immunomodulatory properties. Uteroglobin inhibits soluble phospholipase A(2) activity and binds and perhaps sequesters hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids, and prostaglandins. In addition to its antiinflammatory activities, Uteroglobin manifests antichemotactic, antiallergic, antitumorigenic, and embryonic growth-stimulatory activities. The tissue-specific expression of the Uteroglobin gene is regulated by several steroid hormones, although a nonsteroid hormone, prolactin, further augments its expression in the uterus. Based on its anti-inflammatory and antiallergic properties, Uteroglobin is a potential drug target. The mechanism of Uteroglobin action is likely to be even more complex as it also functions via a putative receptor-mediated pathway.

References

Mukherjee AB, et al. (1999). Uteroglobin: a novel cytokine Cell Mol Life Sci. 55(5): 771-87.Klug J, et al. (2000). Uteroglobin/Clara cell 10-kDa family of proteins: nomenclature committee report. Ann. N. Y. Acad. Sci. 923: 348-54.Laukaitis CM, et al. (2005). Evolution of the secretoglobins: a genomic and proteomic view. Biological Journal of the Linnean Society. 84 (3): 493-501.Mukherjee AB, et al. (2007). Uteroglobin: a steroid-inducible immunomodulatory protein that founded the Secretoglobin superfamily. Endocr Rev. 28(7): 707-25.Kido T, et al. (2011). FOXA1 plays a role in regulating secretoglobin 1a1 expression in the absence of CCAAT/enhancer binding protein activities in lung in vivo. Am J Physiol Lung Cell Mol Physiol. 300(3): L441-52.

NCBI and Uniprot Product Information

• NCBI GI #: 6755947
• NCBI GeneID: 22287
• NCBI Accession #: NP_035811.1
• NCBI GenBank Nucleotide #: NM_011681.2
• UniProt Accession #: Q06318
• Molecular Weight: 10,519 Da
• NCBI Official Full Name: uteroglobin
• NCBI Official Synonym Full Names: secretoglobin, family 1A, member 1 (uteroglobin)
• NCBI Official Symbol: Scgb1a1
• NCBI Official Synonym Symbols: UG; UGB; Utg; CC10; CC16; CCSP; PCB-BP
• NCBI Protein Information: uteroglobin; Blastokinin; CCPBP; PCB-binding protein; clara cell 17 kDa protein; clara cell phospholipid-binding protein; clara cell secretory protein; clara cells 10 kDa secretory protein; secretoglobin family 1A member 1
• UniProt Protein Name: Uteroglobin
• Protein Family: Uteroglobin
• UniProt Gene Name: Scgb1a1
• UniProt Synonym Gene Names: Cc10; Ugb; Utg; CCPBP; CC10
• UniProt Entry Name: UTER_MOUSE

Uniprot Description

SCGB1A1: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2. Belongs to the secretoglobin family.

Protein type: Secreted, signal peptide; Secreted; Inhibitor; Cell cycle regulation

Cellular Component: extracellular space; rough endoplasmic reticulum; endoplasmic reticulum; cytoplasm; extracellular region; nuclear envelope; intracellular; secretory granule

Molecular Function: phospholipase A2 inhibitor activity

Biological Process: negative regulation of interleukin-4 production; negative regulation of interleukin-13 production; negative regulation of T cell proliferation; response to cytokine stimulus; negative regulation of interferon-gamma production; regulation of inflammatory response; negative regulation of interleukin-5 production; negative regulation of transcription from RNA polymerase II promoter; regulation of mRNA stability; signal transduction