SCCA1 recombinant protein
SCCA1 Protein (Active)
Applications
ELISA, SDS-Page
Purity
>95% by SDS-PAGE
Synonyms
SCCA1; SCCA1 Protein (Active); Squamous cell carcinoma antigen 1; SCCA-1; Serpin B3; SERPINB3; SCCA1 recombinant protein
Host
E. Coli
Purity/Purification
>95% by SDS-PAGE
Form/Format
Liquid; Each vial contains Tris-HCl (pH7.4 ± 0.2) with 0.02% NaN3.
Concentration
1.1 mg/ml (varies by lot)
Applicable Applications for SCCA1 recombinant protein
ELISA (EIA), SDS-PAGE
Application Notes
MBS355561 SCCA1 recombinant protein has been shown to be immunologically active in ELISA when paired MBS355835 Capture or Detection SCCA1 Antibody and MBS355836 Capture or Detection SCCA1 Antibody. Additionally, MBS355561 has been verified for use as an ELISA Standard with paired with these antibodies.
Preparation and Storage
Upon receipt, aliquot and store at -20 degree C or -80 degree C for long term.
Avoid repeated freeze and thaw cycles.
Avoid repeated freeze and thaw cycles.
Related Product Information for SCCA1 recombinant protein
Description: Recombinant full length human SCCA1 protein with molecular weight 45 kDa.
Background: Squamous cell carcinoma antigen (SCCA) is a member of the ovalbumin family of serine proteinase inhibitors (serpins).SCCA is detected in the superficial andintermediate layers of normal squamous epithelium, whereas the mRNA is detected in the basal and subbasal levels. A neutralform of the protein (SCCA1, or SERPINB3)is found in normal and some malignantsquamous cells, whereas an acidic form (SCCA2, or SERPINB4) is detected exclusively in tumor cells and in the circulation of patients with squamous cell tumors. SCCA1 shares 92% amino acid identity with SCCA2. Thus, the appearance of the acidic fraction of SCCA is correlated with more aggressive tumors . Ray et al. (2005) proposed that IL-4- andIL-13-stimulated SCCA gene expression is mediated via STAT-1 and STAT-6 activation, and by suppressing the production, and most likely by interfering with the signaling of these cytokines, UGinhibits SCCA gene expression associatedwith airway inflammation in asthma.
Background: Squamous cell carcinoma antigen (SCCA) is a member of the ovalbumin family of serine proteinase inhibitors (serpins).SCCA is detected in the superficial andintermediate layers of normal squamous epithelium, whereas the mRNA is detected in the basal and subbasal levels. A neutralform of the protein (SCCA1, or SERPINB3)is found in normal and some malignantsquamous cells, whereas an acidic form (SCCA2, or SERPINB4) is detected exclusively in tumor cells and in the circulation of patients with squamous cell tumors. SCCA1 shares 92% amino acid identity with SCCA2. Thus, the appearance of the acidic fraction of SCCA is correlated with more aggressive tumors . Ray et al. (2005) proposed that IL-4- andIL-13-stimulated SCCA gene expression is mediated via STAT-1 and STAT-6 activation, and by suppressing the production, and most likely by interfering with the signaling of these cytokines, UGinhibits SCCA gene expression associatedwith airway inflammation in asthma.
Similar Products
Product Notes
The SCCA1 (Catalog #AAA355561) is a Recombinant Protein produced from E. Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's SCCA1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), SDS-PAGE. MBS355561 SCCA1 recombinant protein has been shown to be immunologically active in ELISA when paired MBS355835 Capture or Detection SCCA1 Antibody and MBS355836 Capture or Detection SCCA1 Antibody. Additionally, MBS355561 has been verified for use as an ELISA Standard with paired with these antibodies. Researchers should empirically determine the suitability of the SCCA1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SCCA1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
