Human ring finger protein 111 ELISA Kit | RNF111 elisa kit
Human E3 ubiquitin-protein ligase Arkadia, RNF111 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
Uniprot Description
RNF111: Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin- protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.2.-; Ubiquitin ligase; Ligase; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 15q21
Cellular Component: nucleoplasm; protein complex; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; zinc ion binding; SUMO polymer binding; SMAD binding; ligase activity
Biological Process: transcription initiation from RNA polymerase II promoter; protein polyubiquitination; transcription, DNA-dependent; positive regulation of protein ubiquitination; transforming growth factor beta receptor signaling pathway; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; protein ubiquitination; positive regulation of transcription from RNA polymerase II promoter; gene expression; ubiquitin-dependent SMAD protein catabolic process; pattern specification process
Research Articles on RNF111
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Product Notes
The Human RNF111 rnf111 (Catalog #AAA9343330) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9343330 ELISA Kit recognizes Human RNF111. It is sometimes possible for the material contained within the vial of "ring finger protein 111, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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