Regulator of G-protein signaling 2 Recombinant Protein | RGS2 recombinant protein

Recombinant Human Regulator of G-protein signaling 2

Cat. Num. AAA963215

• Gene Names: RGS2; G0S8
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Regulator of G-protein signaling 2; Recombinant Human Regulator of G-protein signaling 2; Cell growth-inhibiting gene 31 protein; G0/G1 switch regulatory protein 8; RGS2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-211aa; Full Length
• Sequence: MQSAMFLAVQHDCRPMDKSAGSGHKSEEKREKMKRTLLKDWKTRLSYFLQNSSTPGKPKTGKKSKQQAFIKPSPEEAQLWSEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT
• Sequence Length: 211

• Production Note: Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to [email protected] for more details.
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-Page

Related Product Information for RGS2 recombinant protein

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving th into their inactive GDP-bound form. May play a role in leukogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.

Product Categories/Family for RGS2 recombinant protein

Signal Transduction

References

A human gene encoding a putative basic helix-loop-helix phosphoprotein whose mRNA increases rapidly in cycloheximide-treated blood mononuclear cells.Siderovski D.P., Heximer S.P., Forsdyke D.R.DNA Cell Biol. 13:125-147(1994)

NCBI and Uniprot Product Information

• NCBI GI #: 4506517
• NCBI GeneID: 5997
• NCBI Accession #: NP_002914.1
• NCBI GenBank Nucleotide #: NM_002923.3
• UniProt Accession #: P41220; Q6I9U5
• Molecular Weight: 40.4 kDa
• NCBI Official Full Name: regulator of G-protein signaling 2
• NCBI Official Synonym Full Names: regulator of G-protein signaling 2
• NCBI Official Symbol: RGS2
• NCBI Official Synonym Symbols: G0S8
• NCBI Protein Information: regulator of G-protein signaling 2
• UniProt Protein Name: Regulator of G-protein signaling 2
• Protein Family: Regulator of G-protein signaling
• UniProt Gene Name: RGS2
• UniProt Synonym Gene Names: G0S8; RGS2
• UniProt Entry Name: RGS2_HUMAN

NCBI Description

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009]

Uniprot Description

RGS2: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein. 4 isoforms of the human protein are produced by alternative initiation.

Protein type: GAPs; Nucleolus; GAPs, misc.

Chromosomal Location of Human Ortholog: 1q31

Cellular Component: cytoplasm; cytosol; internal side of plasma membrane; mitochondrion; neuron projection; nucleolus; nucleus; plasma membrane

Molecular Function: beta-tubulin binding; calmodulin binding; G-protein alpha-subunit binding; GTPase activator activity; protein binding

Biological Process: brown fat cell differentiation; cell cycle; negative regulation of G-protein coupled receptor protein signaling pathway; negative regulation of MAP kinase activity; positive regulation of GTPase activity; positive regulation of microtubule polymerization; regulation of G-protein coupled receptor protein signaling pathway; regulation of translation; relaxation of vascular smooth muscle; spermatogenesis