Rabbit RGS2 Polyclonal Antibody | anti-RGS2 antibody

RGS2 Polyclonal Antibody

Cat. Num. AAA2523577

• Gene Names: RGS2; G0S8
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: RGS2; Polyclonal Antibody; RGS2 Polyclonal Antibody; G0S8; anti-RGS2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1.4mg/mL (varies by lot)
• Sequence Length: 211

• Applicable Applications for anti-RGS2 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Recombinant protein of human RGS2
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colon cancer tissue using RGS2 Polyclonal Antibody at dilution 1:40)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using RGS2 Polyclonal Antibody at dilution 1:40)

Related Product Information for anti-RGS2 antibody

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis.

NCBI and Uniprot Product Information

• NCBI GI #: 4506517
• NCBI GeneID: 5997
• NCBI Accession #: NP_002914.1
• NCBI GenBank Nucleotide #: NM_002923.3
• Molecular Weight: 20,780 Da
• NCBI Official Full Name: regulator of G-protein signaling 2
• NCBI Official Synonym Full Names: regulator of G-protein signaling 2
• NCBI Official Symbol: RGS2
• NCBI Official Synonym Symbols: G0S8
• NCBI Protein Information: regulator of G-protein signaling 2; G0 to G1 switch regulatory 8, 24kD; G0/G1 switch regulatory protein 8; cell growth-inhibiting gene 31 protein; cell growth-inhibiting protein 31; regulator of G-protein signaling 2, 24kDa
• UniProt Protein Name: Regulator of G-protein signaling 2
• Protein Family: Regulator of G-protein signaling
• UniProt Gene Name: RGS2
• UniProt Synonym Gene Names: G0S8; RGS2
• UniProt Entry Name: RGS2_HUMAN

NCBI Description

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009]

Uniprot Description

RGS2: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein. 4 isoforms of the human protein are produced by alternative initiation.

Protein type: Nucleolus; GAPs, misc.; GAPs

Chromosomal Location of Human Ortholog: 1q31

Cellular Component: neuron projection; internal side of plasma membrane; mitochondrion; cytoplasm; nucleolus; plasma membrane; cytosol

Molecular Function: calmodulin binding; protein binding; beta-tubulin binding; GTPase activator activity

Biological Process: regulation of translation; negative regulation of MAP kinase activity; relaxation of vascular smooth muscle; negative regulation of G-protein coupled receptor protein signaling pathway; positive regulation of microtubule polymerization; brown fat cell differentiation; spermatogenesis; cell cycle; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity