RGS2 recombinant protein

RGS2 (Regulator of G Protein Signalling 2) Recombinant, Human

Cat. Num. AAA638172

• Gene Names: RGS2; G0S8
• Applications: ELISA
• Purity: Highly Purified; ~95% by SDS-PAGE.
• Synonyms: RGS2; RGS2 (Regulator of G Protein Signalling 2) Recombinant; Human; RGS2 recombinant protein

• Host: E Coli
• Purity/Purification: Highly Purified; ~95% by SDS-PAGE.
• Form/Format: Supplied as a liquid in 10mM Tris, pH 8.0, 0.1% Triton X-100, 0.002% sodium azide.

• Applicable Applications for RGS2 recombinant protein: ELISA (EL/EIA)
• Application Notes: Suitable for use in Mass Spectrometry and SDS Gel.
• Preparation and Storage: For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months.

SDS-Page

(SDS: Analysis of RGS2 Recombinant Protein. 4-20% SDS gradient gel. Coomassie blue staining.)

Related Product Information for RGS2 recombinant protein

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis.

Product Categories/Family for RGS2 recombinant protein

Molecular Biology; MB-G Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 4506517
• NCBI GeneID: 5997
• NCBI Accession #: NP_002914.1
• NCBI GenBank Nucleotide #: NM_002923.3
• UniProt Accession #: P41220; Q6I9U5
• Molecular Weight: 24,382 Da
• NCBI Official Full Name: regulator of G-protein signaling 2
• NCBI Official Synonym Full Names: regulator of G-protein signaling 2, 24kDa
• NCBI Official Symbol: RGS2
• NCBI Official Synonym Symbols: G0S8
• NCBI Protein Information: regulator of G-protein signaling 2; G0/G1 switch regulatory protein 8; cell growth-inhibiting protein 31; G0 to G1 switch regulatory 8, 24kD; cell growth-inhibiting gene 31 protein
• UniProt Protein Name: Regulator of G-protein signaling 2
• Protein Family: Regulator of G-protein signaling
• UniProt Gene Name: RGS2
• UniProt Synonym Gene Names: G0S8; RGS2
• UniProt Entry Name: RGS2_HUMAN

NCBI Description

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009]

Uniprot Description

RGS2: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein. 4 isoforms of the human protein are produced by alternative initiation.

Protein type: GAPs; GAPs, misc.; Nucleolus

Chromosomal Location of Human Ortholog: 1q31

Cellular Component: neuron projection; internal side of plasma membrane; mitochondrion; cytoplasm; plasma membrane; nucleolus; cytosol

Molecular Function: calmodulin binding; protein binding; beta-tubulin binding; GTPase activator activity

Biological Process: regulation of translation; negative regulation of MAP kinase activity; relaxation of vascular smooth muscle; negative regulation of G-protein coupled receptor protein signaling pathway; positive regulation of microtubule polymerization; brown fat cell differentiation; spermatogenesis; cell cycle; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity