I-309 Recombinant Active Protein | CCL1 active protein

I-309, Human Recombinant

Cat. Num. AAA650934

• Gene Names: CCL1; P500; SISe; TCA3; I-309; SCYA1
• Purity: Molecular Biology Grade; 99% by SDS-PAGE and HPLC analyses.
• Synonyms: I-309 Recombinant; I-309; Human Recombinant; CCL1 active protein

• Host: Recombinant human
• Purity/Purification: Molecular Biology Grade; 99% by SDS-PAGE and HPLC analyses.
• Form/Format: Sterile filtered and lyophilized without additives.

• Biological Activity: Determined by a chemotaxis assay using total human T cell population. Significant chemotaxis was achieved at a concentration range of 1-100ng/ml.
• Endotoxin Level: 0.1ng/ug
• Preparation and Storage: The lyophilized protein is stable at room temperature. Stored desiccated below 0 degree C. Reconstituted I-309 should be stored in working aliquots at- 20 degree C. Lyophilized Human I-309 can be reconstituted in water to a concentration of 1.0mg/ml. This solution can be diluted into other buffered solutions or stored at -20 degree C for future use.

Related Product Information for CCL1 active protein

Human I-309, an 8.5kD protein containing 74 amino acid residues, is a small glycoprotein secreted by activated T-lymphocytes and structurally related to other CC chemokines.

Product Categories/Family for CCL1 active protein

Growth Factors; Cytokines; Growth Factors-I-309

NCBI and Uniprot Product Information

• NCBI GI #: 37360916
• NCBI GeneID: 6346
• UniProt Accession #: Q76BR7; P22362
• Molecular Weight: 8.5kD
• NCBI Official Full Name: I-309
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 1
• NCBI Official Symbol: CCL1
• NCBI Official Synonym Symbols: P500; SISe; TCA3; I-309; SCYA1
• NCBI Protein Information: C-C motif chemokine 1; OTTHUMP00000163800; inflammatory cytokine I-309; small-inducible cytokine A1; T lymphocyte-secreted protein I-309; small inducible cytokine A1 (I-309, homologous to mouse Tca-3)
• UniProt Protein Name: I-309
• Protein Family: Cyclin
• UniProt Gene Name: SCYA1
• UniProt Entry Name: Q76BR7_HUMAN

NCBI Description

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine receptor CCR8. [provided by RefSeq]

Uniprot Description

CCL1: Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space

Molecular Function: chemokine activity

Biological Process: cellular calcium ion homeostasis; viral reproduction; immune response; chemotaxis; signal transduction