RNA-binding motif protein, Y chromosome, family 1 member A1 Recombinant Protein | RBMY1A1 recombinant protein

Recombinant Human RNA-binding motif protein, Y chromosome, family 1 member A1

Cat. Num. AAA1029535

• Gene Names: RBMY1A1; RBM; RBM1; RBM2; RBMY; YRRM1; YRRM2; RBMY1C
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: RNA-binding motif protein; Y chromosome; family 1 member A1; Recombinant Human RNA-binding motif protein; RNA-binding motif protein 1; RNA-binding motif protein 2; Y chromosome RNA recognition motif 1; hRBMY; RBMY1A1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-459aa; Partial
• Sequence: MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRTSKSRGFAFITFENPADAKNAAKDMNGKSLHGKAIKVEQAKKPSFQSGGRRRPPASSRNRSPSGSLRSARGSRGGTRGWLPSHEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPSSRETRDYAPPHRDYAYRDYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDRYGRSWESYSSCGDFHYCDREHVCRKDQRNPPS
• Sequence Length: 496

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for RBMY1A1 recombinant protein

RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs.

Product Categories/Family for RBMY1A1 recombinant protein

Epigenetics and Nuclear Signaling

References

A Y chromosome gene family with RNA-binding protein homology candidates for the azoospermia factor AZF controlling human spermatogenesis.Ma K., Inglis J.D., Sharkey A., Bickmore W.A., Hill R.E., Prosser E.J., Speedson R.M., Thomson E.J., Jobling M.Cell 75:1287-1295(1993) The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A., Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C.Nature 423:825-837(2003) Structure and organization of the RBMY genes on the human Y chromosome transposition and amplification of an ancestral autosomal hnRNPG gene.Chai N.-N., Zhou H., Hernandez J., Najmabadi H., Bhasin S., Yen P.H.Genomics 49:283-289(1998) Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long arm.Elliott D.J., Millar M.R., Oghene K., Ross A., Kiesewetter F., Pryor J., McIntyre M., Hargreave T.B., Saunders P.T.K., Vogt P.H., Chandley A.C., Cooke H.Proc. Natl. Acad. Sci. U.S.A. 94:3848-3853(1997) T-STAR/ETOILE a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis.Venables J.P., Vernet C., Chew S.L., Elliott D.J., Cowmeadow R.B., Wu J., Cooke H.J., Artzt K., Eperon I.C.Hum. Mol. Genet. 8:959-969(1999) RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing.Venables J.P., Elliott D.J., Makarova O.V., Makarov E.M., Cooke H.J., Eperon E.C.Hum. Mol. Genet. 9:685-694(2000) hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1.Hofmann Y., Wirth B.Hum. Mol. Genet. 11:2037-2049(2002) The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis.Elliott D.J.Int. J. Androl. 27:328-334(2004) The testis-specific human protein RBMY recognizes RNA through a novel mode of interaction.Skrisovska L., Bourgeois C.F., Stefl R., Grellscheid S.-N., Kister L., Wenter P., Elliott D.J., Stevenin J., Allain F.H.-T.EMBO Rep. 8:372-379(2007)

NCBI and Uniprot Product Information

• NCBI GI #: 4826974
• NCBI GeneID: 5940
• NCBI Accession #: NP_005049.1
• NCBI GenBank Nucleotide #: NM_005058.2
• UniProt Accession #: P0DJD3; Q15376; Q15377; Q15414; Q6NSB5; Q86VU6; Q8NHR0
• Molecular Weight: 55.9 kDa
• NCBI Official Full Name: RNA-binding motif protein, Y chromosome, family 1 member A1
• NCBI Official Synonym Full Names: RNA binding motif protein, Y-linked, family 1, member A1
• NCBI Official Symbol: RBMY1A1
• NCBI Official Synonym Symbols: RBM; RBM1; RBM2; RBMY; YRRM1; YRRM2; RBMY1C
• NCBI Protein Information: RNA-binding motif protein, Y chromosome, family 1 member A1
• UniProt Protein Name: RNA-binding motif protein, Y chromosome, family 1 member A1
• Protein Family: RNA-binding motif protein
• UniProt Gene Name: RBMY1A1
• UniProt Synonym Gene Names: RBM1; RBM2; YRRM1; YRRM2; hRBMY
• UniProt Entry Name: RBY1A_HUMAN

NCBI Description

This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq, Jul 2008]

Uniprot Description

RBMY1A1: RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3.

Protein type: RNA splicing

Chromosomal Location of Human Ortholog: Yq11.223

Cellular Component: nucleus

Molecular Function: mRNA binding; nucleotide binding; protein binding

Biological Process: mRNA processing; regulation of alternative nuclear mRNA splicing, via spliceosome; RNA splicing

Disease: Spermatogenic Failure, Y-linked, 2