RBMY1A1 Antibody | anti-RBMY1A1 antibody

RBMY1A1, CT (RBMY1A1,RNA-binding motif protein, Y chromosome, family 1 member A1/C,RBM1, RBM2, YRRM1)

Cat. Num. AAA6006827

• Gene Names: RBMY1A1; RBM; RBM1; RBM2; RBMY; YRRM1; YRRM2; RBMY1C
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A and peptide affinity chromatography
• Synonyms: RBMY1A1; CT (RBMY1A1; RNA-binding motif protein; Y chromosome; family 1 member A1/C; RBM1; RBM2; YRRM1); Anti -RBMY1A1; anti-RBMY1A1 antibody

• Isotype: IgG
• Specificity: Recognizes human RBMY1A1
• Purity/Purification: Purified by Protein A and peptide affinity chromatography
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
• Concentration: 0.34mg/ml (varies by lot)

• Applicable Applications for anti-RBMY1A1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: Western Blot: 1:1000; Optimal dilutions to be determined by the researcher. Other applications not tested.
• Grade: Affinity Purified
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 468-496 in the C-terminal region of human RBMY1A1
• Preparation and Storage: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in NCI-H292 cell line lysates (35ug/lane) using MBS6006827. This demonstrates that MBS6006827 detected the RBMY1A1 protein (arrow).)

Related Product Information for anti-RBMY1A1 antibody

This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq].

Product Categories/Family for anti-RBMY1A1 antibody

Antibodies; Abs to Binding Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 4826974
• NCBI GeneID: 5940
• NCBI Accession #: NP_005049.1
• NCBI GenBank Nucleotide #: NM_005058.2
• UniProt Accession #: P0DJD3; Q15376; Q15377; Q15414; Q6NSB5; Q86VU6; Q8NHR0
• NCBI Official Full Name: RNA-binding motif protein, Y chromosome, family 1 member A1
• NCBI Official Synonym Full Names: RNA binding motif protein, Y-linked, family 1, member A1
• NCBI Official Symbol: RBMY1A1
• NCBI Official Synonym Symbols: RBM; RBM1; RBM2; RBMY; YRRM1; YRRM2; RBMY1C
• NCBI Protein Information: RNA-binding motif protein, Y chromosome, family 1 member A1; RNA binding protein; RNA-binding motif protein 1; RNA-binding motif protein 2; y chromosome RNA recognition motif 1; RNA binding motif protein, Y chromosome, family 1, member A1; RNA-binding motif protein, Y chromosome, family 1 member A1/C
• UniProt Protein Name: RNA-binding motif protein, Y chromosome, family 1 member A1
• Protein Family: RNA-binding motif protein
• UniProt Gene Name: RBMY1A1
• UniProt Synonym Gene Names: RBM1; RBM2; YRRM1; YRRM2; hRBMY
• UniProt Entry Name: RBY1A_HUMAN

NCBI Description

This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq, Jul 2008]

Uniprot Description

RBMY1A1: RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3.

Protein type: RNA splicing

Chromosomal Location of Human Ortholog: Yq11.223

Cellular Component: nucleus

Molecular Function: mRNA binding; protein binding; nucleotide binding

Biological Process: RNA splicing; mRNA processing; regulation of alternative nuclear mRNA splicing, via spliceosome

Disease: Spermatogenic Failure, Y-linked, 2