Uncoupling Protein 3, Rat Peptide | Coq7 peptide
Uncoupling Protein 3, Rat (UCP3) (Control Peptide)
Applications
ELISA
Purity
Highly PurifiedHighly purified
Synonyms
Uncoupling Protein 3; Rat; Rat (UCP3) (Control Peptide); Coq7 peptide
Host
Rat
Specificity
The 18 AA rat immunogenic peptide sequence is identical in mouse UCP3 (18/18 aa), 94% in hamster, 66% in canine, 61% in bovine, 63% in monkey, 38% in human.
Purity/Purification
Highly Purified
Highly purified
Highly purified
Form/Format
Supplied as a liquid. in PBS, pH 7.4 and 0.02% sodium azide.
Applicable Applications for Coq7 peptide
ELISA (EL/EIA)
Preparation and Storage
-20 degree C
Related Product Information for Coq7 peptide
An 18 amino acid peptide sequence between the 3rd and 4th transmembrane domain of rat UCP3.
Rat/mouse UCP3 long form (UCP3L) is a 308 aa mitochondrial uncoupling protein (1, 2). It is only 57% and 73% homologous with human UCP1 and UCP2 respectively. Like other UCPs, UCP3 is predicted to contain 6 transmembrane domains. The UCP3S lacks the 6th transmembrane domain and it is only 275 aa long (2). UCP3 has preferential expression in muscle and it is unaffected by cold acclimation.
The regulation of body weight depends upon the calorie intake and expenditure. It is a very complex and highly regulated process. It involves multiples neural circuits with specific neuropeptides, neurotransmitter transporters and receptors and influenced by peripheral signals. The product of obese gene (Leptin) may influence many of these processes. White and brown adipose tissues (WAT and BAT, respectively) play a central role in body weight and energy expenditure. WAT is the major site for energy storage via triglyceride synthesis and mobilization via lipolysis. Uncoupling proteins (UCP1-4) are a family of mitochondria transprt proteins that play a critical role in thermoregulatory heat production and maintenance of basal metabolic rate. BAT is able to dissipate energy as heat via uncoupled mitochondrial respiration by a mitochondrial anion carrier, uncoupling protein 1 (UCP1). UCP1 is predicted to contain 6 trans-membrane (TM) domains, a putative purine nucleotide-binding domain (PNBD) and three-mitochondrial energy transfer protein domains (ETPDs). Both amino and C-termini are predicted to be cytoplasmic. UCP1 is a member of the mitochondrial carrier protein family, which includes the ATP/ADP translocator, the phosphate, the 2-oxoglutarate/malate and the citrate (tricarboxylate) carriers. UCP1 plays an important role in thermoregulation in hibernating animals, neonates, and it contributes to rodent cold- and diet induced thermogenesis.
Because of the restricted expression of UCP1 and the lack of BAT in adult animals and humans, UCP1 may not be important in body weight regulation/energy expenditure in adults. Recently a novel UCP2, a homologue of UCP1, has been identified. In contrast with UCP1, UCP2 is widely expressed in adult human tissues and it is unregulated in WAT in response to fat intake. UCP2 is 59% homologous with UCP1. In the WAT of ob/ob and db/db mice, UCP2 expression is greatly elevated when compared to lean animals. Therefore, UCP2 has been implicated in the regulation of energy balance, body weight, and thermoregulation. Skeletal muscle contributes up to 40% of whole body epinephrine-induced thermogenesis in humans.
Another homologue of UCPs, UCP3, has been cloned from human skeletal muscle. Human UCP3 protein (312 aa) has 71% and 57% homology with UCP2 and UCP1, respectively. The long (309 aa) and mature form of UCP3 is designated as UCP3L; UCP3s lacks the 6th potential TM domain and the PNBD domain implicated in the control of coupling efficiency of UCP1. Both forms of UCP3 are expressed in muscle. UCP3 expression is highly specific for skeletal muscle and it is unaffected by cold acclimation. It is also expressed in BAT of animals. UCP3 could play a critical role in energy expenditure and its regulation.
Rat/mouse UCP3 long form (UCP3L) is a 308 aa mitochondrial uncoupling protein (1, 2). It is only 57% and 73% homologous with human UCP1 and UCP2 respectively. Like other UCPs, UCP3 is predicted to contain 6 transmembrane domains. The UCP3S lacks the 6th transmembrane domain and it is only 275 aa long (2). UCP3 has preferential expression in muscle and it is unaffected by cold acclimation.
The regulation of body weight depends upon the calorie intake and expenditure. It is a very complex and highly regulated process. It involves multiples neural circuits with specific neuropeptides, neurotransmitter transporters and receptors and influenced by peripheral signals. The product of obese gene (Leptin) may influence many of these processes. White and brown adipose tissues (WAT and BAT, respectively) play a central role in body weight and energy expenditure. WAT is the major site for energy storage via triglyceride synthesis and mobilization via lipolysis. Uncoupling proteins (UCP1-4) are a family of mitochondria transprt proteins that play a critical role in thermoregulatory heat production and maintenance of basal metabolic rate. BAT is able to dissipate energy as heat via uncoupled mitochondrial respiration by a mitochondrial anion carrier, uncoupling protein 1 (UCP1). UCP1 is predicted to contain 6 trans-membrane (TM) domains, a putative purine nucleotide-binding domain (PNBD) and three-mitochondrial energy transfer protein domains (ETPDs). Both amino and C-termini are predicted to be cytoplasmic. UCP1 is a member of the mitochondrial carrier protein family, which includes the ATP/ADP translocator, the phosphate, the 2-oxoglutarate/malate and the citrate (tricarboxylate) carriers. UCP1 plays an important role in thermoregulation in hibernating animals, neonates, and it contributes to rodent cold- and diet induced thermogenesis.
Because of the restricted expression of UCP1 and the lack of BAT in adult animals and humans, UCP1 may not be important in body weight regulation/energy expenditure in adults. Recently a novel UCP2, a homologue of UCP1, has been identified. In contrast with UCP1, UCP2 is widely expressed in adult human tissues and it is unregulated in WAT in response to fat intake. UCP2 is 59% homologous with UCP1. In the WAT of ob/ob and db/db mice, UCP2 expression is greatly elevated when compared to lean animals. Therefore, UCP2 has been implicated in the regulation of energy balance, body weight, and thermoregulation. Skeletal muscle contributes up to 40% of whole body epinephrine-induced thermogenesis in humans.
Another homologue of UCPs, UCP3, has been cloned from human skeletal muscle. Human UCP3 protein (312 aa) has 71% and 57% homology with UCP2 and UCP1, respectively. The long (309 aa) and mature form of UCP3 is designated as UCP3L; UCP3s lacks the 6th potential TM domain and the PNBD domain implicated in the control of coupling efficiency of UCP1. Both forms of UCP3 are expressed in muscle. UCP3 expression is highly specific for skeletal muscle and it is unaffected by cold acclimation. It is also expressed in BAT of animals. UCP3 could play a critical role in energy expenditure and its regulation.
Product Categories/Family for Coq7 peptide
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
20,140 Da
NCBI Official Full Name
ubiquinone biosynthesis protein COQ7 homolog
NCBI Official Synonym Full Names
coenzyme Q7 homolog, ubiquinone (yeast)
NCBI Official Symbol
Coq7
NCBI Protein Information
ubiquinone biosynthesis protein COQ7 homolog; demethyl-Q 7; timing protein clk-1 homolog; coenzyme Q biosynthesis protein 7 homolog; Coenzyme q (ubiquinone) biosynthetic enzyme (DHPB methyltransferase) 7
UniProt Protein Name
Ubiquinone biosynthesis protein COQ7 homolog
Protein Family
UniProt Gene Name
Coq7
UniProt Entry Name
COQ7_RAT
NCBI Description
may play a roel in ubiquinone biosynthesis [RGD, Feb 2006]
Uniprot Description
Function: Involved in lifespan determination in ubiquinone-independent manner. Involved in ubiquinone biosynthesis. Potential central metabolic regulator
By similarity.
Cofactor: Binds 2 iron ions per subunit
By similarity.
Pathway: Cofactor biosynthesis; ubiquinone biosynthesis.
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note: Synthesized as a preprotein that is imported into the mitochondrial matrix, where the sequence is cleaved off and the mature protein becomes loosely associated with the inner membrane
By similarity.
Sequence similarities: Belongs to the COQ7 family.
Research Articles on Coq7
Similar Products
Product Notes
The Coq7 coq7 (Catalog #AAA658741) is a Peptide produced from Rat and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Uncoupling Protein 3, Rat can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA). Researchers should empirically determine the suitability of the Coq7 coq7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Uncoupling Protein 3, Rat, Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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