Rat Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) ELISA Kit | PDK1 elisa kit

Rat Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) ELISA Kit

Cat. Num. AAA454661

• Reactivity: Rat
• Synonyms: Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1); Rat Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) ELISA Kit; PDK1 elisa kit

• Reactivity: Rat
• Sequence Length: 434

• Samples: Serum, plasma, tissue homogenates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 0.156-10ng/mL
• Sensitivity: 0.057ng/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 3183109
• NCBI GeneID: 116551
• UniProt Accession #: Q63065
• Molecular Weight: 49,081 Da
• NCBI Official Full Name: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
• NCBI Official Synonym Full Names: pyruvate dehydrogenase kinase 1
• NCBI Official Symbol: Pdk1
• NCBI Protein Information: pyruvate dehydrogenase kinase, isozyme 1
• UniProt Protein Name: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
• Protein Family: [Pyruvate dehydrogenase
• UniProt Gene Name: Pdk1
• UniProt Synonym Gene Names: Pdh; PDH kinase 1

NCBI Description

catalyzes the phosphorylation and inactivation of the pyruvate dehydrogenase complex [RGD, Feb 2006]

Uniprot Description

Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.