NCBI and Uniprot Product Information
NCBI Description
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. [provided by RefSeq, Nov 2009]
Uniprot Description
NPY: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. Belongs to the NPY family.
Protein type: Hormone; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 7p15.1
Cellular Component: Golgi apparatus; extracellular space; cell; extracellular region
Molecular Function: G-protein coupled receptor activity; neuropeptide hormone activity; neuropeptide Y receptor binding; calcium channel regulator activity; receptor binding
Biological Process: blood circulation; behavior; adult feeding behavior; G-protein signaling, coupled to cyclic nucleotide second messenger; cell proliferation; synaptic transmission; neuropeptide signaling pathway; calcium ion transport; regulation of blood pressure; positive regulation of appetite; digestion; regulation of appetite; feeding behavior; cerebral cortex development; cell motility; neurite development; central nervous system neuron development
Research Articles on NP-Y
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Product Notes
The Rat NP-Y npy (Catalog #AAA264669) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA264669 ELISA Kit recognizes Rat NP-Y. It is sometimes possible for the material contained within the vial of "Neuropeptide Y (NP-Y), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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