Rabbit PDE5A Antibody | anti-PDE5A antibody

Rabbit Anti-PDE5A

Cat. Num. AAA375156

• Gene Names: PDE5A; CN5A; PDE5; CGB-PDE
• Reactivity: Mouse, Rat, Human
• Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
• Purity: Unpurified
• Synonyms: PDE5A; Rabbit Anti-PDE5A; CGB PDE antibody; CGBPDE antibody; cGMP binding cGMP specific 3' 5' cyclic nucleotide phosphodiesteraseantibody; cGMP binding cGMP specific 35 cyclic nucleotide phosphodiesterase antibody; cGMP binding cGMP specificphosphodiesterase antibody; cGMP binding/cGMP specific phosphodiesterase antibody; cGMP specific 3'5' cyclicphosphodiesterase antibody; CN5A antibody; CN5N antibody; PDE 5 antibody; PDE 5A antibody; PDE5antibody; PDE5A1 antibody; Phosphodiesterase 5A antibody; Phosphodiesterase 5A cGMP specificantibody; anti-PDE5A antibody

• Host: Rabbit
• Reactivity: Mouse, Rat, Human
• Specificity: Selectively detects proteins corresponding to the PDE5A isoform
• Purity/Purification: Unpurified
• Form/Format: Diluted serum
• Sequence Length: 875

• Applicable Applications for anti-PDE5A antibody: Immunohistochemistry (IHC) Paraffin, Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: Optimal antibody dilution should be determined by titration, however as a guideline use at 1:20000 for WB
• Target Antigen: PDE5A
• Immunogen: Designed from the C-terminal region common to the 5A isoform
• Research Areas: Metal ion binding; phosphodiesterase activity

Testing Data

NCBI and Uniprot Product Information

• NCBI GI #: 365776143
• NCBI GeneID: 8654
• UniProt Accession #: O76074; O75026; O75887; Q86UI0; Q86V66; Q9Y6Z6; A0AV69; A8K2C4
• Molecular Weight: 94,805 Da
• NCBI Official Full Name: phosphodiesterase 5A
• NCBI Official Synonym Full Names: phosphodiesterase 5A, cGMP-specific
• NCBI Official Symbol: PDE5A
• NCBI Official Synonym Symbols: CN5A; PDE5; CGB-PDE
• NCBI Protein Information: cGMP-specific 3',5'-cyclic phosphodiesterase; cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase; cGMP-specific phosphodiesterase PDE5A2; cGMP-specific phosphodiesterase type 5A; phosphodiesterase isozyme 5
• UniProt Protein Name: cGMP-specific 3',5'-cyclic phosphodiesterase
• UniProt Gene Name: PDE5A
• UniProt Synonym Gene Names: PDE5; CGB-PDE
• UniProt Entry Name: PDE5A_HUMAN

NCBI Description

This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

PDE5A: a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Phosphorylation is regulated by binding of cGMP to the two allosteric sites. Sildenafil (Viagra) is a highly selective and potent inhibitor of PDE5A. Alternative splicing results in four transcript variants encoding distinct isoforms.

Protein type: EC 3.1.4.35; Phosphodiesterase; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 4q27

Cellular Component: cytosol

Molecular Function: 3',5'-cyclic-GMP phosphodiesterase activity; metal ion binding; cGMP binding; 3',5'-cyclic-nucleotide phosphodiesterase activity

Biological Process: positive regulation of MAP kinase activity; negative regulation of T cell proliferation; regulation of cGMP metabolic process; cGMP catabolic process; blood coagulation; signal transduction