Western Blot (WB)
(WB Suggested Anti-TAF1C Antibody Titration: 2.5ug/mlELISA Titer: 1:12500Positive Control: Jurkat cell lysateTAF1C is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells)
Rabbit anti-Human TAF1C Polyclonal Antibody | anti-TAF1C antibody
TAF1C antibody - C-terminal region
Western Blot (WB)
(WB Suggested Anti-TAF1C Antibody Titration: 2.5ug/mlELISA Titer: 1:12500Positive Control: Jurkat cell lysateTAF1C is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells)
Western Blot (WB)
(WB Suggested Anti-TAF1C Antibody Titration: 2.5ug/mlELISA Titer: 1:12500Positive Control: Jurkat cell lysateTAF1C is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells)
Target Description: Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. TAF1C is the largest SL1-specific TAF.
NCBI and Uniprot Product Information
NCBI Description
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]
Uniprot Description
Function: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3. Ref.8 Ref.9
Subunit structure: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with MYC and RRN3. Interacts with p53/TP53; the interaction prevents the association of SL1/TIF-IB with UBTF and represses RNA polymerase I transcription. Ref.1 Ref.7 Ref.8 Ref.10
Subcellular location: Nucleus.
Sequence caution: The sequence BAD92831.1 differs from that shown. Reason: Probable cloning artifact.
Research Articles on TAF1C
Similar Products
Product Notes
The TAF1C taf1c (Catalog #AAA3204211) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TAF1C antibody - C-terminal region reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TAF1C can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the TAF1C taf1c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: AKLPPQRDTP GCATTPPHSQ ASSVRATRSQ QHTPVLSSSQ PLRKKPRMGF. It is sometimes possible for the material contained within the vial of "TAF1C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
