Testing Data
Rabbit anti-Human, Mouse CD130/gp130 Antibody | anti-CD130/gp130 antibody
CD130/gp130 (Ab-782) Antibody
IHC: 1:50~1:100
IF: 1:100~1:500
ELISA: 1:20000
Testing Data
Testing Data
Western Blot (WB)
(Western blot analysis of extracts from Jurkat cells, using CD130/gp130 (Ab-782) antibody. Western blot analysis of extracts from NIH/3T3 cells, using CD130/gp130 (Ab-782) antibody.)
Western Blot (WB)
(Western blot analysis of extracts from Jurkat cells, using CD130/gp130 (Ab-782) antibody. Western blot analysis of extracts from NIH/3T3 cells, using CD130/gp130 (Ab-782) antibody.)
Testing Data
(Peptide-+)
Testing Data
(Peptide-+)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
Uniprot Description
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (). Has a role in embryonic development (). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (). Required for expression of TRPA1 in nociceptive neurons (). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (). Required for normal trabecular bone mass and cortical bone composition ().
Research Articles on CD130/gp130
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Product Notes
The CD130/gp130 il6st (Catalog #AAA859145) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CD130/gp130 (Ab-782) Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CD130/gp130 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA). WB: 1:500~1:3000 IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:20000. Researchers should empirically determine the suitability of the CD130/gp130 il6st for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD130/gp130, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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