Rabbit anti-Human GRIK5 Polyclonal Antibody | anti-GRIK5 antibody

GRIK5, NT (GRIK5, GRIK2, Glutamate receptor, ionotropic kainate 5, Excitatory amino acid receptor 2, Glutamate receptor KA-2) (Biotin)

Cat. Num. AAA6304406

• Gene Names: GRIK5; KA2; EAA2; GRIK2; GluK5
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: GRIK5; Polyclonal Antibody; NT (GRIK5; GRIK2; Glutamate receptor; ionotropic kainate 5; Excitatory amino acid receptor 2; Glutamate receptor KA-2) (Biotin); Glutamate receptor KA-2; anti-GRIK5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-GRIK5 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: GRIK5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-129 amino acids from the N-terminal region of human GRIK5.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(GRIK5 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the GRIK5 antibody detected the GRIK5 protein (arrow).)

Related Product Information for anti-GRIK5 antibody

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. [provided by RefSeq].

Product Categories/Family for anti-GRIK5 antibody

Antibodies; Receptors

References

Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009): Gill, M.B., et al. J. Biol. Chem. 284(21):14503-14512(2009). Arai, S., et al. Psychiatr. Genet. 19(1):6-13(2009). Fotheringham, J., et al. J Neuroimmune Pharmacol 3(2):105-116(2008). Shibata, H., et al. Psychiatry Res 141(1):39-51(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 29029597
• NCBI GeneID: 2901
• NCBI Accession #: NP_002079.3
• NCBI GenBank Nucleotide #: NM_002088.4
• UniProt Accession #: Q16478; Q8WWG8
• Molecular Weight: 109,658 Da
• NCBI Official Full Name: glutamate receptor ionotropic, kainate 5 isoform 2
• NCBI Official Synonym Full Names: glutamate ionotropic receptor kainate type subunit 5
• NCBI Official Symbol: GRIK5
• NCBI Official Synonym Symbols: KA2; EAA2; GRIK2; GluK5
• NCBI Protein Information: glutamate receptor ionotropic, kainate 5
• UniProt Protein Name: Glutamate receptor ionotropic, kainate 5
• Protein Family: Glutamate receptor ionotropic
• UniProt Gene Name: GRIK5
• UniProt Synonym Gene Names: GRIK2; GluK5; EAA2; KA2
• UniProt Entry Name: GRIK5_HUMAN

NCBI Description

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Description

GluR KA2: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L- glutamate >> AMPA >> NMDA = 1S,3R-ACPD. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: presynaptic membrane; postsynaptic membrane; kainate selective glutamate receptor complex; endoplasmic reticulum; dendrite; postsynaptic density; plasma membrane; terminal button; perikaryon; cell junction

Molecular Function: identical protein binding; kainate selective glutamate receptor activity; extracellular-glutamate-gated ion channel activity; SH3 domain binding; PDZ domain binding

Biological Process: synaptic transmission, glutamatergic; synaptic transmission; ionotropic glutamate receptor signaling pathway; regulation of synaptic vesicle fusion to presynaptic membrane; positive regulation of neuron apoptosis; regulation of excitatory postsynaptic membrane potential; receptor clustering; protein retention in ER; establishment of cellular localization