Western Blot (WB)
(Western blot analysis of 293 cell lysate using TNFRSF6B antibody.)
Rabbit anti-Human TNFRSF6B Antibody | anti-TNFRSF6B antibody
TNFRSF6B Antibody
Gene Names
TNFRSF6B; M68; TR6; DCR3; M68E; DJ583P15.1.1
Reactivity
Human
Applications
Western Blot, Immunohistochemistry
Purity
Affinity purification
Synonyms
TNFRSF6B; TNFRSF6B Antibody; DCR3; TR6; anti-TNFRSF6B antibody
Host
Rabbit
Reactivity
Human
Isotype
IgG
Purity/Purification
Affinity purification
Sequence Length
300
Applicable Applications for anti-TNFRSF6B antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
WB: 1:500-1:2000
IHC: 1:50-1:200
IHC: 1:50-1:200
Immunogen
Recombinant protein of human TNFRSF6B
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.
Western Blot (WB)
(Western blot analysis of 293 cell lysate using TNFRSF6B antibody.)
Western Blot (WB)
(Western blot analysis of 293 cell lysate using TNFRSF6B antibody.)
Related Product Information for anti-TNFRSF6B antibody
The tumor necrosis factor receptor family, which includes TNF-RI, Fas, DR3, DR4, DR5, and DR6, plays an important role in the regulation of apoptosis in various physiological systems (1, 2). The receptors are activated by a family of cytokines that include TNF, FasL, and TRAIL. They are characterized by a highly conserved extracellular region containing cysteine-rich repeats and a conserved intracellular region of about 80 amino acids termed the death domain (DD). The DD is important for transducing the death signal by recruiting other DD containing adaptor proteins (FADD, TRADD, RIP) to the death-inducing signaling complex (DISC), resulting in activation of caspases.
Product Categories/Family for anti-TNFRSF6B antibody
References
1. Nagata, S. (1997) Cell 88, 355-365. 2. Thorburn, A. (2004) Cell. Signal. 16, 139-144. 3. Sheridan, J.P. et al. (1997) Science 277, 818-821. 4. Marsters, S.A. et al. (1997) Curr. Biol. 7, 1003-1006. 5. Pitti, R.M. et al. (1998) Nature 396, 699-703. 6. Liu, X. et al. (2005) Cancer Res. 65, 9169-9175. 7. Spalding, A.C. et al. (2002) Oncogene 21, 260-271. 8. Bernard, D. et al. (2001) J. Biol. Chem. 276, 27322-27328.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
33kDa
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 6B
NCBI Official Synonym Full Names
TNF receptor superfamily member 6b
NCBI Official Symbol
TNFRSF6B
NCBI Official Synonym Symbols
M68; TR6; DCR3; M68E; DJ583P15.1.1
NCBI Protein Information
tumor necrosis factor receptor superfamily member 6B
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 6B
Protein Family
UniProt Gene Name
TNFRSF6B
UniProt Synonym Gene Names
DCR3; TR6; DcR3
NCBI Description
This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]
Uniprot Description
Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.
Research Articles on TNFRSF6B
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Product Notes
The TNFRSF6B tnfrsf6b (Catalog #AAA8503775) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TNFRSF6B Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TNFRSF6B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500-1:2000 IHC: 1:50-1:200. Researchers should empirically determine the suitability of the TNFRSF6B tnfrsf6b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TNFRSF6B, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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