Rabbit DcR3 Polyclonal Antibody | anti-DcR3 antibody

DcR3 (G287) Polyclonal Antibody

Cat. Num. AAA3002764

• Gene Names: TNFRSF6B; M68; TR6; DCR3; M68E; DJ583P15.1.1
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: DcR3; Polyclonal Antibody; DcR3 (G287) Polyclonal Antibody; Tumor necrosis factor receptor superfamily member 6B; Decoy receptor 3; Decoy receptor for Fas ligand; M68; TNFRSF6B; DCR3; TR6; UNQ186/PRO212; anti-DcR3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: DcR3 (G287) polyclonal antibody detects endogenous levels of DcR3 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 300

• Applicable Applications for anti-DcR3 antibody: Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: IHC: 1:50-1:200; IF: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 261-310 of Human DcR3.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Testing Data

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analysis of DcR3 (G287) pAb in paraffin-embedded human colon carcinoma tissue.)

Related Product Information for anti-DcR3 antibody

Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated by two distinct cell surface receptors, designated TNF-R1 and TNF-R2, which are expressed on most cell types. TNF function is primarily mediated through TNF-R1 signaling. Both receptors belong to the growing TNF receptor superfamily which includes FAS antigen and CD40. TNF-R1 contains a cytoplasmic motif, termed the "death domain, " that has been found to be necessary for the transduction of the apoptotic signal. The death domain is also found in several other receptors, including FAS, DR2 (or TRUNDD), DR3 (death receptor 3), DR4, DR5 and DR6. TRUNDD, DR4 and DR5 are receptors for the apoptosis-inducing cytokine TRAIL. Non-death domain-containing receptors, designated decoy receptor 1 (DcR1) or TRID, DcR2 and DcR3, associate with specific ligands and may play a role in cellular resistance to apoptotic stimuli.

NCBI and Uniprot Product Information

• NCBI GI #: 4507585
• NCBI GeneID: 8771
• NCBI Accession #: NP_003814.1
• NCBI GenBank Nucleotide #: NP_003814.1
• UniProt Accession #: O95407
• Molecular Weight: ~ 33kDa
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 6B
• NCBI Official Synonym Full Names: TNF receptor superfamily member 6b
• NCBI Official Symbol: TNFRSF6B
• NCBI Official Synonym Symbols: M68; TR6; DCR3; M68E; DJ583P15.1.1
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 6B
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 6B
• UniProt Gene Name: TNFRSF6B
• UniProt Synonym Gene Names: DCR3; TR6; DcR3
• UniProt Entry Name: TNF6B_HUMAN

NCBI Description

This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]

Uniprot Description

TNFRSF6B: Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: extracellular space

Molecular Function: protein binding; receptor activity

Biological Process: apoptosis; negative regulation of apoptosis