Rabbit FOXP1 Antibody | anti-FOXP1 antibody

Rabbit anti FOXP1 antibody

Cat. Num. AAA462159

• Gene Names: FOXP1; QRF1; 12CC4; hFKH1B; HSPC215; FLJ23741; MGC12942; MGC88572; MGC99551
• Reactivity: Human, Mouse, Rat, Bovine, Chicken
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: The Rabbit IgG is purified by Epitope Affinity Purification.
• Synonyms: FOXP1; Rabbit anti FOXP1 antibody; Rabbit anti-FOXP1; Forkhead box P1; anti-FOXP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat, Bovine, Chicken
• Specificity: This antibody only recognizes ~52 kDa of human FOXP1. The other species are not tested.
• Purity/Purification: The Rabbit IgG is purified by Epitope Affinity Purification.
• Form/Format: This affinity purified antibody is supplied in sterile phosphatebuffered saline (pH7.2) containing antibody stabilizer
• Concentration: Size: 100 ug/200 ul (varies by lot)

• Applicable Applications for anti-FOXP1 antibody: ELISA, Western Blot, Immunohistochemistry
• Application Notes: Western Blot: 0.1-1 ug/ml; ELISA: 0.01-0.1 ug/ml; Immunoprecipitation: 2-5 ug/ml; Immunohistochemistry: 0.5-2 ug/ml
• Antigen Preparation: A synthetic peptide corresponding to the C-terminus of human FOXP1 protein. This sequence is identical to human, mouse, rat, bovine and chicken
• Positive Control: Hela
• Cellular Location: Nuclear
• Preparation and Storage: The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

Testing Data

Related Product Information for anti-FOXP1 antibody

FOXP1 (a 431 amino acid protein) is a member of the forkhead/winged-helix family of transcriptional regulators and is highly conserved across mammals. FOXP3 is essential for normal immune homeostasis. FOXP3 is stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, at low level in CD4 positive/CD25 negative cells, and is absent in CD4 negative/CD8 positive T cells. FOXP3 may be a master regulatory gene and a more specific marker of regulatory T cells than other T cells.

References

Kristen Jepsen, et al, Cooperative regulation in development by SMRT and FOXP1 (2008), GENES & DEVELOPMENT 22:740-745.

NCBI and Uniprot Product Information

• NCBI GI #: 18644886
• NCBI GeneID: 27086
• NCBI Accession #: NP_116071.2
• NCBI GenBank Nucleotide #: NM_032682.4
• UniProt Accession #: Q548T7; Q6IAJ1; Q8IXF4; Q8N2P0; Q8NAN6; Q8TEA2; Q9BSG9; Q9H334
• Molecular Weight: 52 kDa
• NCBI Official Full Name: forkhead box protein P1 isoform 1
• NCBI Official Synonym Full Names: forkhead box P1
• NCBI Official Symbol: FOXP1
• NCBI Official Synonym Symbols: QRF1; 12CC4; hFKH1B; HSPC215; FLJ23741; MGC12942; MGC88572; MGC99551
• NCBI Protein Information: forkhead box protein P1; OTTHUMP00000213499; OTTHUMP00000213500; OTTHUMP00000213501; OTTHUMP00000213502; OTTHUMP00000213503; OTTHUMP00000213504; OTTHUMP00000213506; OTTHUMP00000213507; OTTHUMP00000213508; glutamine-rich factor 1; fork head-related protein like B
• UniProt Protein Name: 12CC4
• Protein Family: Forkhead box protein
• UniProt Gene Name: FOXP1
• UniProt Entry Name: Q548T7_HUMAN

NCBI Description

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

Uniprot Description

Sequence similarities: Contains 1 fork-head DNA-binding domain. SAAS SAAS001766