Western Blot (WB)
(Anti-FOXP1 antibody, MBS175433, Western blottingLane 1: Rat Spleen Tissue LysateLane 2: COLO320 Cell Lysate )
Rabbit FOXP1 Polyclonal Antibody | anti-FOXP1 antibody
Anti-FOXP1 antibody
Western Blot (WB)
(Anti-FOXP1 antibody, MBS175433, Western blottingLane 1: Rat Spleen Tissue LysateLane 2: COLO320 Cell Lysate )
Western Blot (WB)
(Anti-FOXP1 antibody, MBS175433, Western blottingLane 1: Rat Spleen Tissue LysateLane 2: COLO320 Cell Lysate )
Immunohistochemistry (IHC)
(Anti-FOXP1 antibody, MBS175433, IHC(P)IHC(P): Human Rectal Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-FOXP1 antibody, MBS175433, IHC(P)IHC(P): Human Rectal Cancer Tissue )
Background: FOXP1("forkhead box P1") is a gene that is necessary for the proper development of the brain and lung in mammals. It is a member of the large FOX family of transcription factors. This gene belongs to subfamily P of the forkhead box(FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region(3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. It was shown that the embryonic stem cell(ESC)-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency, including OCT4, NANOG, NR5A2, and GDF3, while concomitantly repressing genes required for ESC differentiation. This isoform also promotes the maintenance of ESC pluripotency and contributes to efficient reprogramming of somatic cells into induced pluripotent stem cells. These results reveal a pivotal role for an Alternative splicing event in the regulation of pluripotency through the control of critical ESC-specific transcriptional programs(2).
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
FOXP1: Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development. Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; C2H2-type zinc finger protein; Transcription factor; Cell cycle regulation
Chromosomal Location of Human Ortholog: 3p14.1
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; androgen receptor binding; sequence-specific DNA binding; metal ion binding
Biological Process: transcription from RNA polymerase II promoter; positive regulation of smooth muscle cell proliferation; response to lipopolysaccharide; osteoclast differentiation; endothelial cell activation; regulation of transcription from RNA polymerase II promoter; regulation of monocyte differentiation; macrophage activation; monocyte activation; regulation of inflammatory response; regulation of interleukin-1 beta secretion; regulation of tumor necrosis factor production; negative regulation of transcription, DNA-dependent; negative regulation of B cell apoptosis
Disease: Mental Retardation With Language Impairment And With Or Without Autistic Features
Research Articles on FOXP1
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Product Notes
The FOXP1 foxp1 (Catalog #AAA175433) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-FOXP1 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's FOXP1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the FOXP1 foxp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FOXP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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